The effect of meptazinol in the spinal cord on carrageenan-induced hyperalgesia was investigated. The latency of paw withdrawal (PWL) to a thermal stimulus was used as an index of inflammatory hyperalgesia in awake rats. Intrathecal (i.t.) injection of 10 and 100mg meptazinol markedly increased the PWL of the carrageenan-injected paw (P, 0:01). The PWL of the non-injected paw was not detectably affected by the administration of meptazinol at the doses tested. I.t. injection of naloxone (5mg) or atropine (1mg) alone exhibited no effect on the PWLs of either the carrageenan-injected or non-injected paw. Pretreatment with naloxone, but not atropine, completely blocked the meptazinol-induced anti-hyperalgesia. These observations suggested that mu opioid receptor rather than muscarinic acetylcholine receptor may be involved in the anti-hyperalgesia of meptazinol in the spinal cord.

选用苄基氯，经过芳香族烯烃的游离基加成、缩台、氢解脱苄基等反应以及光学异构体的拆分，合成了福辛普利（fosinopril）的重要中间体[R（R*, S*）[（2甲基1丙酰氧基丙氧基）（4苯基丁基）氧腾基]乙酸，并改进了部分反应条件。