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2004年12月24日

【期刊论文】Biotransformation of triptolide by Cunninghamella blakesleana

果德安， Lili Ning， a， b， Jixun Zhan， Guiqin Qu， Lei Zhong， Hongzhu Guo， Kaishun Bi b and Dean Guo a， *

Tetrahedron xx(0000)xxx-xxx，-0001，（）：

-1年11月30日

摘要

Biotransformation of triptolide 1 by Cunninghamella blakesleana (AS 3.970) was carried out. Seven biotransformation products were obtained and four of them were characterized as new compounds. On the basis of their NMR and mass spectral data, their structures were characterized as 5α-hydroxytriptolide 2, 1β-hydroxytriptolide 3, triptodiolide 4, 16-hydroxytriptolide 5, triptolidenol 6, 19α-hydroxytriptolide 7 and 19β-hydroxytriptolide 8 All the new transformed products (2, 3, 7 and 8) were found to exhibit potent in vitro cytotoxicity against some human tumor cell lines.

biotransformation， triptolide， Cunninghamella blakesleana.，

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果德安邀请

北京大学，北京

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