Abstract-Eight new camphorato platinum complexes have been synthesized and evaluated for their in vitro cytotoxicity against HL-60 human leukemia, 3AO human ovarian carcinoma, BEL-7402 human hepatocarcinoma, and A549 human lung carcinoma cell lines. Most complexes showed good cytotoxic activity against the above-selected cell lines. Among the complexes, two compounds were assayed for their in vivo antitumor activity against LS-174T human colon carcinoma cells implanted in mice. One complex exhibited not only higher in vivo antitumor activity, but also less toxicity than oxaliplatin when it was administered intravenously at a dose of 6mg/kg three times.

A novel 1D neutral coordination polymer, {[Cu(dtmp)(dmf)Cl2]dmf}n (1) (dtmp=1,6-di(triazole-1-yl-methyl)-4-methylphenol, dmf=dimethyl formamide) was synthesized by reacting CuCl2 Æ 2H2O with the dtmp ligand. The crystal and molecular structure of the complex was determined by X-ray diffraction, in which the coordination geometry around the copper center is slightly distorted trigonal bypyramidal. One-dimensional chains have been formed through the metal and the ligand via oordination bonds, which are assembled further into a two-dimensional network by inter-chain synergic π-π stacking and hydrogen bonding.

Several chiral copper(II) complexes of optically active Schiff bases (R,R)-4a-c, which have central seven-membered chelate rings, have been synthesized and characterized. X-ray single crystal analysis of a typical compound indicated that the complex is monomeric and the geometry around the metal atom is very distorted tetrahedral. All the complexes have been tested as catalysts for asymmetric oxidation of methyl phenyl sulfide. The mechanism of the catalytic reaction in the presence of these complexes has been tentatively elucidated.

Supramolecular compounds assembled by dinuclear zinc(II) species containing Robson-type macrocycles and diverse organic subunits (4,4 -bipyridine, 2,2 -bipyridine, pyrazine, 4-aminopyridine, 4-pyridinecarboxylate, pyridine, and quinoline) are reviewed. Various structural motifs such as molecular ladder, molecular ladder element and so forth have been generated. Structural attributes associated with each motif will be elucidated based on unambiguous single crystal X-ray analysis. Hydrogen bonding especially of the non-classical type, involved in the assembly are also discussed because of its crucial impact on the architecture of the final product.

A dinuclear manganese macrocyclic complex with functional pendant arms, [Mn2(II)HL2](ClO4), has been prepared by the cyclocondensation of sodium 2,6-diformyl-4-methylphenolate with N,N-bis(2-aminoethyl)-N-(2-hydroxybenzyl)amine and subsequent transmetallation of Mn(II)(ClO4)2. In the molecular structure of the complex, each pendant arm is bound to an adjacent manganese atom and both arms lie on the same side of the resulting tetra-imine macrocycle. Each manganese(II) ion is in a distorted octahedral configuration. The variable-temperature magnetism and the cyclic voltammogram of the complex have also been investigated. In the catalytic study, this compound exhibits a high activity for catalyzing disproportionation of H2O2 to O2.