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邓大君, Yu Sun, Dajun Deng, Wei-Cheng You, Hua Bai, Lian Zhang, Jing Zhou, Lin Shen, Jun-Ling Ma, Yu-Quan Xie, and Ji-You Li
Vol. 10, 5087-5093, August 1, 2004,-0001,():
-1年11月30日
Purpose: Inactivation of p16 by aberrant methylation of CpG islands is a frequent event in carcinomas and precancerouslesions of various organs, including the stomach. Theaim of this study is to investigate the relationship betweenp16 methylation and mali
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【期刊论文】Methylation of CpG islands of p16 associated with progression of primary gastric carcinomas
邓大君, Daya Luo*, Baozhen Zhang*, Lingbo Lv, Shengyan Xiang, Yahang Liu, Jiafu Ji and Dajun Deng
,-0001,():
-1年11月30日
Inactivation of p16 by methylation of CpG islands is a frequent early event in gastric carcinogenesis. Thepositive relationship between p16 methylation and the clinical characteristics of gastric carcinomas (GC) hasnot been reported to date. In the presen
CpG Islands, DHPLC, gastric carcinoma, methylation, p16, quantification
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邓大君, ZHOU Pin, , GU Lian-kun, ZHOU Jing, WANG Ru-ming, ZHAO Zi-hou, DENG Da-jun*
Chinese Journal of Cancer Research 17 (3): 190-192, 2005,-0001,():
-1年11月30日
Objective: To setup an animal model of gastric carcinogenesis by Helicobacter pylori (Hp) for basic, preventionand therapeutic research of Hp-related diseases. Methods: 22 young male Mongolian gerbils were administrated withsuspension of Hp strain TN2 by
Helicobacter pylori, Mongolian gerbil, Gastric carcinogenesis, Intraepithelial neoplasia
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【期刊论文】Hypermethylation of metallothionein-3 CpG island in gastric carcinoma
邓大君, Dajun Deng, , Wa'el El-Rifai, Jiafu Ji, Budong Zhu, Paul Trampont, Jiyou Li, Michael F.Smith and Steven M.Powell
Carcinogenesis vol.24 no.1 pp. 25-29, 2003,-0001,():
-1年11月30日
The expression of metallothionein (MT)-3 is often markedly reduced in gastric carcinoma (GC). The molecular mechanism of this MT-3 downregulation is unknown. Transcriptional silencing of MT-3 by methylation of CpG island was investigated by nucleotide seq
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邓大君, FEN LIU, *, KAIFENG PAN, XUEMEI ZHANG, ‡, YANG ZHANG, LIAN ZHANG, JUNLING MA, CAIXUAN DONG, LIN SHEN, §, JIYOU LI, ¶, DAJUN DENG, DONGXIN LIN, ‡ and WEICHENG YOU*
GASTROENTEROLOGY 2006; 130: 1975-1984,-0001,():
-1年11月30日
Background & Aims: To screen the genetic variants incyclooxygenase-2 (COX-2), and evaluate their effects onCOX-2 expression and risk of gastric cancer (GC) and itsprecursors, a population-based study was conducted inLinqu County, Shangdong Province, an ar
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