Objective: The object of this study was to analysis the therapeu-tic effects of microsurgical excision in cases with the large or giant cerebellopontine angle meningioma. Methods: We retro-spectively analyzed the 56 patients who suffered from the large or giant cerebellopontine angle meningioma and underwent the microsurgical therapy, for which the suboccipital-retrosigmoidal approach was adopted in 38 cases, the temporal-occipital cra-niotomy, presigmoidal approach in 6 cases, the temporal-occipi-tal craniotomy, inferotemporal tentorium cerebelli approach-ing cases, and the temporal-occipital craniotomy, supratentorial or infratentorial allied approach in 4 cases. Results: The tumors of 44 cases were all resected (Simpson 1, 11), with a total resection rate of 78.6%, and there was no operative mortality. After sur-gery, symptoms improved in 40 cases and remained unchanged in 10 cases. Among 54 cases, recrudescence was seen in 2 cases (3.7%) and being able to take care of themselves in 50 cases (92.6%) at 6 months through 6 years follow-up after surgery. Conclusion: A rationally selected surgical approach, a micro-scopic technology applied in the operation to appropriately treat and protect vein, nerve and brain stem, which can ideally excise the tumors, together can increase the survival ability of patients.