Ebis is the intelligent environmental biotechnological informatics software developed for judging the effectiveness of the microorganism strain in the industrial wastewater treatment system (IWTS) at the optimal status. The parameter, as the objective function for the judgment, is the minimum reactor volume (Vmin) calculated by Ebis. The rationality and the universality of Ebis were demonstrated in the domestic sewage treatment system (DSTS) with the data published in USA and China. Fhhh strain's potential for treating the purified terephthalic acid (PTA) has been proved in this research. It suggests that Ebis would be useful and universal for predicating the technique effectiveness in both DSTS and IWTS.