Institute of Forensic Medicine, west China University of MedicaI scIences, 610044 chengdu, PR Institute of Forensic Medicine, University of Cologne, 50823 KOin, FRG Since its introduction in 1985, VNTR polymorphism analysis has rapidly become a routine technique for forensic biology and population genetics But sO far there ore stlll some controversies surrounding VNTR polymorphisms. one of them being whether they violate the assumptions of Hardy-Weinberg equilibrium (HWE). Conceming biostotical tests the only significant dfiference between VNTR loci analysed by AMp-FLP and tradifionaI serological markers is that there are more alleles at a particular VNTR locus. so that not all genotypes can be observed in a relatively sinail sample Therefore. some indireat methods have been suggested to test HWE forthese VNTR Ioci (1-4), but the efficiency ofthem was not evaluated. our Purpose here is to Compare the efficiency of dfiferent statisticaI tests and to suggest a more sensitive new modification