In this paper, the principle of mirror image is used to transform the problem of wave diffraction from a circular cylinder in front of orthogonal vertical walls into the problem of diffraction of four symmetric incident waves from four symmetrically arranged circular cylinders, and then the eigenfunction expansion of velocity potential and Grafs addition theorem are used to give the analytical solution to the wave diffraction problem. The relation of the total wave force on cylinder to the distance between the cylinder and orthogonal vertical walls and the incidence angle of wave is also studied by numerical computation.