Propyl-glycoside lacter, a new α-hydroxy acids derivative, was synthesized byesterification between lactic acid and propl-glycoside, instead oftransesteritication as reported previously, in a non-aqeous medium using immobilxed lipase as biocatalyst. A con ersion of 66% was achieved by the optimixation o the reaction conditions. Lipase activitywas found to be reduced when exposed to high conccentration mechanism of the enzymtic esterfication reaction. Additon of molecular sieves eliminated hydrolysis of the produced ester and allowed glycoside conversion rising to 75%