Synthesis of 1,2,3,4-Tetrahydroeudistomin U Derivatives and Preliminary In Vitro Antitumor Evaluation，成果详细信息-中国科技论文在线

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期刊论文

Synthesis of 1,2,3,4-Tetrahydroeudistomin U Derivatives and Preliminary In Vitro Antitumor Evaluation

闻韧， Jianbin Zheng ，， Zhiwen Zhang ， Lingling Zhao ， Xianyi Sha ， Xiaochun Dong ， l and Ren Wen

Pharmaceutical Biology 2008, Vol. 46, No.4, pp. 273-278，-0001，（）：

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摘要/描述

A series of novel 2-substituted 1.2,3A-tetrahydroeudislomin g derivatives wcrc synthesized by the key Pictet Spenglcr cyclization reaction and their in rilvo antitumot activities were evaluated using Prricularia orrzae Cavara and Caco-2 cancer eel Is. Most of the 2-alkyl-1,2,3,4-teirahydroeudistomin U compounds (19-23) showed potent inhibitory activities in both o['thc biological tests. Preliminary structure-activity relationships are also presented.

关键词: Antitumor, Caco-2 cancer cell, 1-(indol-3-yl)-1,2,3,4-tetrahydro-β-carboline, Pyricularia oryzde ，

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