Whether in industry or in our human life, we will encounter many lubrication problems. A good lubricant not only should have good performance, but also should meet the needs of the specific conditions. Here we give some examples about the difficult problems in lubrication and their solutions. These examples are: (i) hydrolysis and emulsion of ZDTP; (ii) corrosion of chlorowax; (iii) coexistence of green compressor oil and cryogen (R-134A); (iv) lubrication of cystoscope and catheter. On the same time, some achievements in lubrication field provided by Lubrication Chemistry Laboratory of Shanghai University will be introduced in this paper.