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赵金垣

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期刊论文

Echinacoside rescues the SHSY5Y neuronal cells from TNFa-induced apoptosis

赵金垣Min Deng a Jin Yuan Zhao b* Peng Fei Tu c Yong Jiang c Zheng Bin Li d Yao Hong Wang b

European Journal of Pharmacology 505(2004)11-18,-0001,():

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摘要/描述

We investigated the neuroprotective effect of echinacoside, one of the phenylethanoids isolated from the stems of Cistanches salsa, a Chinese herbal medicine, on tumor necrosis factor-alpha (TNFa)-induced apoptosis in human neuroblastoma (SHSY5Y) cells. Treatment of cultured SHSY5Y cells with TNFa 100 ng ml 1 for 36 h stimulated apoptosis, as demonstrated by typical morphological changes, cell viability, DNA laddering, annexin-V binding, intracellular reactive oxygen species, mitochondrial membrane potential and caspase-3 activity. However, simultaneous treatment with echinacoside (1, 10 or 100 Ag ml 1) attenuated the TNFa-mediated apoptosis. The antiapoptotic action of echinacoside was partially dependent on antioxidative stress effects, maintenance of mitochondria function, inhibition of caspase-3 activity and was also associated with increasing the expression of the antiapoptotic protein Bcl2. Thus, echinacoside has the neuroprotective capacity to antagonize TNFa-induced apoptosis in SHSY5Y cells and may be useful in treating some neurodegenerative diseases. D 2004 Elsevier B.V. All rights reserved.

【免责声明】以下全部内容由[赵金垣]上传于[2005年01月26日 00时15分10秒],版权归原创者所有。本文仅代表作者本人观点,与本网站无关。本网站对文中陈述、观点判断保持中立,不对所包含内容的准确性、可靠性或完整性提供任何明示或暗示的保证。请读者仅作参考,并请自行承担全部责任。

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