中国科技论文在线

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2007年05月22日

【期刊论文】Synthesis and bioactivity of 4-alkyl (aryl) thioquinazoline derivatives

杨松， Song Yang， Zhi Li， Linhong Jin， Baoan Song， Gang Liu， Jiang Chen， Zhuo Chen， Deyu Hu， Wei Xue and Ruiqing Xu

S. Yang et al. Bioorg. Med. Chem. Lett. 17 (2007) 2193-2196，-0001，（）：

-1年11月30日

Some S'-substituted 4-alkyl (aryl) thioquinazoline derivatives were synthesized through thioetherification reaction of 4-chloroquinazolines 2 and thiol compounds 1 refluxed in acetone in the presence of K2CO3. Their structures were verified by elemental analysis, IR, 1H NMR, and 13C NMR. The compounds were evaluated for their anti-proliferative activities against some cancer cells in vitro by MTT method. Among them, 3c, 3a, 3d, 3f, and 3l were highly effective against PC3 cells and 3a-3m showed weak activities against Bcap37 and BGC823 cells. The IC50 value of 3c, 3a, 3d, 3f, and3l against PC3 cell was 1. 8, 5. 6, 8. 1, 8. 7, and 8. 9 μM, respectively.

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2007年05月22日

【期刊论文】Indium Trichloride-Mediated Facile Synthesis of 3-(Substituted methylthio)-4-phenyl-5-(3, 4, 5-trimethoxyphenyl)-4H-1, 2, 4-triazole in Water†

杨松， YANG Song， LIU， Jie， SONG， Bao-An， JIN， Lin-Hong， HU， De-Yu

Chinese Journal of Chemistry, 2006, 24, 1263-1266，-0001，（）：

-1年11月30日

摘要

An environmentally benign and efficient process for the preparation of 3-(substituted methylthio)-4-phenyl-5-(3, 4, 5-trimethoxyphenyl)-4H-1, 2, 4-triazole was achieved by the reaction of 4-phenyl-5-(3, 4, 5-trimethoxyphenyl)-4H-1, 2, 4-triazole-3-thiol with different halides in aqueous media mediated by indium trichloride in high yields.

thioether， 1,， 2,， 4-triazole， indium trichloride， synthesis

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2007年05月22日

【期刊论文】Synthesis and Antifungal Activity of Novel Chiral α-Aminophosphonates Containing Fluorine Moiety

杨松， YANG， SONG， GAO， Xing-Wen， DIAO， Chun-Ling， Bao-An， JIN， Lin-Hong， XU， Guang-Fang， ZHANG， Guo-Ping， WANG， Wei， HU， De-Yu， XUE， ZHOU， Xia， LU， Ping

Chinese Journal of Chemistry, 2006, 24, 1581-1588，-0001，（）：

-1年11月30日

摘要

Chiral α-aminophosphonates were synthesized using (R) or (S)-1-phenylethylamine in the presence of BF3•Et2O under microwave irradiation in moderate to good yields. The new compounds were identified by 1H NMR, 19F NMR, IR and elemental analysis. Their antifungal activities were evaluated and some compounds were found to exhibit excellent antifungal activities. To the best of our knowledge, this is the first report on antifungal activity of chiral α-aminophosphonates containing fluorine moiety.

Chiral， aminophosphonate， fluorine moiety， antifungal activity， microwave irradiation， synthesis

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2007年05月22日

【期刊论文】Indium-Mediated Facile Preparation of 2-(Heterocyclic thio)-1-(2, 3, 4-trimethoxyphenyl) ethanone in Aqueous Media

杨松， Song Yang， Bao-An Song， Hua Zhang， De-Yu Hu， Lin-Hong Jin， and Gang Liu

J. Heterocyclic Chem., 41, 617 (2004)，-0001，（）：

-1年11月30日

摘要

An environmentally benign and efficient process for the preparation of 1-(2, 3, 4-trimethoxyphenyl)-2-substituted heterocyclic thio ethanone derivatives was achieved by the reactions of mercapto compounds with 2-bromo-1-(2, 3, 4-trimethoxyphenyl) ethanone in water mediated by indium in very high yields. Antifungal activities of the compounds were examined and moderate activity was obtained.

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2007年05月22日

【期刊论文】Diisopropyl {(4-methylbenzothiazol-2-ylamino)[4-(trifluoromethyl)phenyl]methyl}-Phosphonate

杨松， Song Yang， Baoan Song， Guoping Zhang， Linhong Jin， Deyu Hu and Wei Xue

Acta Cryst. (2005). E61, o1662-o1664，-0001，（）：

-1年11月30日

摘要

In the title compound, C22H26F3N2O3PS, there are two independent molecules in the asymmetric unit. The two molecules differ in the orientation of the benzene ring with respect to the benzothiazole group [dihedral angles 58. 6 (2) and 71. 6 (2)0]. In the crystal structure, symmetry-related molecules are linked by N—H· · ·O hydrogen bonds.

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