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杨松, 宋宝安, 吴扬兰, 金林红, 刘刚, 胡德禹, 卢平
有机化学2004年第24卷第10期1292-1295/Chinese Journal of Organic Chemistry Vol. 24, 2004, No. 10, 1292-1295,-0001,():
-1年11月30日
利用含氟苯基亚胺与亚磷酸酯反应,合成了新型含氟a-氨基膦酸酯,通过元素分析、红外光谱、质谱、核磁共振氢谱对其结构进行了表征. X射线单晶衍射测试结果表明:化合物为三斜晶系,空间群P1, a=1. 0178(6)nm, b=1. 0354(6)nm, c=2. 2534(13)nm, a=77. 413(10)0, β=78. 340(10)0, γ=77. 540(10)0, V=2. 233(2)nm, Z=4, Dc=1. 289Mg•m-3, μ=0. 175mm-1, F(000)=904. 0, 最终偏离因子R=0. 0728, wR=0. 1724.
a-氨基膦酸酯, 合成, 晶体结构
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杨松, Song Yang, , Baoan Song, Yanpin Hong, Linhong Jin, and Deyu Hu
Journal of Chemical Crystallography, Vol. 35, No. 11, November 2005,-0001,():
-1年11月30日
Molecular and crystal structure of N-(6-methoxybenzothiazol-2-yl)-1-(4-fluorophenyl)-O, O-dipropyl-α-aminophosphonate, C21H26FN2O4PS, have been determined by single-crystal X-ray diffraction study. The title compound is tetragonal, with a = 21. 35 (3) Ǻ, c = 20. 16 (5) Ǻ, Z = 16, Dx = 1. 308 Mg/m3, μ(MoKα) = 0. 247 mm−1, and space group is I41/a. The structure was solved by direct method and refined to a final R = 0. 0687 for 2370 reflections with I > 2σ(I). The compound shows a fully delocalized benzothiazole system with a sp2 hybridization of the N(2). There is a strong intermolecular hydrogen bond between P=O and NH. The crystal structure is stabilized by a strong intermolecularN-H· · ·O hydrogen bond.
Crystal structure, α-aminophosphonate, fungicide.,
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【期刊论文】Synthesis and bioactivity of 4-alkyl (aryl) thioquinazoline derivatives
杨松, Song Yang, Zhi Li, Linhong Jin, Baoan Song, Gang Liu, Jiang Chen, Zhuo Chen, Deyu Hu, Wei Xue and Ruiqing Xu
S. Yang et al. Bioorg. Med. Chem. Lett. 17 (2007) 2193-2196,-0001,():
-1年11月30日
Some S'-substituted 4-alkyl (aryl) thioquinazoline derivatives were synthesized through thioetherification reaction of 4-chloroquinazolines 2 and thiol compounds 1 refluxed in acetone in the presence of K2CO3. Their structures were verified by elemental analysis, IR, 1H NMR, and 13C NMR. The compounds were evaluated for their anti-proliferative activities against some cancer cells in vitro by MTT method. Among them, 3c, 3a, 3d, 3f, and 3l were highly effective against PC3 cells and 3a-3m showed weak activities against Bcap37 and BGC823 cells. The IC50 value of 3c, 3a, 3d, 3f, and3l against PC3 cell was 1. 8, 5. 6, 8. 1, 8. 7, and 8. 9 μM, respectively.
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杨松, YANG, SONG, GAO, Xing-Wen, DIAO, Chun-Ling, Bao-An, JIN, Lin-Hong, XU, Guang-Fang, ZHANG, Guo-Ping, WANG, Wei, HU, De-Yu, XUE, ZHOU, Xia, LU, Ping
Chinese Journal of Chemistry, 2006, 24, 1581-1588,-0001,():
-1年11月30日
Chiral α-aminophosphonates were synthesized using (R) or (S)-1-phenylethylamine in the presence of BF3•Et2O under microwave irradiation in moderate to good yields. The new compounds were identified by 1H NMR, 19F NMR, IR and elemental analysis. Their antifungal activities were evaluated and some compounds were found to exhibit excellent antifungal activities. To the best of our knowledge, this is the first report on antifungal activity of chiral α-aminophosphonates containing fluorine moiety.
Chiral, aminophosphonate, fluorine moiety, antifungal activity, microwave irradiation, synthesis
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杨松, Song Yang, Bao-An Song, Hua Zhang, De-Yu Hu, Lin-Hong Jin, and Gang Liu
J. Heterocyclic Chem., 41, 617 (2004),-0001,():
-1年11月30日
An environmentally benign and efficient process for the preparation of 1-(2, 3, 4-trimethoxyphenyl)-2-substituted heterocyclic thio ethanone derivatives was achieved by the reactions of mercapto compounds with 2-bromo-1-(2, 3, 4-trimethoxyphenyl) ethanone in water mediated by indium in very high yields. Antifungal activities of the compounds were examined and moderate activity was obtained.
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