中国科技论文在线

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2007年05月22日

【期刊论文】2-(1 H-咪唑-1-基)-1-(2, 3, 4-三甲氧基)苯乙酮肟酯新化合物合成与生物活性研究

杨松，宋宝安，李正名，廖仁安，刘刚，胡德禹

有机化学2002年第22卷第5期345-349/Chinese Journal of Organic Chemistry Vol. 22, 2002, No. 5, 345-349，-0001，（）：

-1年11月30日

首次合成了12个2-(1 H-咪唑-1-基)-1-(2, 3, 4-三甲氧基)苯乙酮肟酯新化合物, 并经元素分析、红外光谱、核磁共振氢谱对其结构进行了表征, 初步生物活性测试表明, 有些化合物具有杀菌活性. 研究了这些新化合物结构与光谱特征之间的关系.

2,， 3,， 4-三甲氧基苯乙酮肟，酯，咪唑，合成

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2007年05月22日

【期刊论文】Synthesis and crystal structure of N-(6-methoxylbenzothiazol-2-yl)-1-(4-fluorophenyl)-O, O-dipropyl-α-aminophosphonate

杨松， Song Yang，， Baoan Song， Yanpin Hong， Linhong Jin， and Deyu Hu

Journal of Chemical Crystallography, Vol. 35, No. 11, November 2005，-0001，（）：

-1年11月30日

摘要

Molecular and crystal structure of N-(6-methoxybenzothiazol-2-yl)-1-(4-fluorophenyl)-O, O-dipropyl-α-aminophosphonate, C21H26FN2O4PS, have been determined by single-crystal X-ray diffraction study. The title compound is tetragonal, with a = 21. 35 (3) Ǻ, c = 20. 16 (5) Ǻ, Z = 16, Dx = 1. 308 Mg/m3, μ(MoKα) = 0. 247 mm−1, and space group is I41/a. The structure was solved by direct method and refined to a final R = 0. 0687 for 2370 reflections with I > 2σ(I). The compound shows a fully delocalized benzothiazole system with a sp2 hybridization of the N(2). There is a strong intermolecular hydrogen bond between P=O and NH. The crystal structure is stabilized by a strong intermolecularN-H· · ·O hydrogen bond.

Crystal structure， α-aminophosphonate， fungicide.，

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2007年05月22日

【期刊论文】Indium-Mediated Facile Preparation of 2-(Heterocyclic thio)-1-(2, 3, 4-trimethoxyphenyl) ethanone in Aqueous Media

杨松， Song Yang， Bao-An Song， Hua Zhang， De-Yu Hu， Lin-Hong Jin， and Gang Liu

J. Heterocyclic Chem., 41, 617 (2004)，-0001，（）：

-1年11月30日

摘要

An environmentally benign and efficient process for the preparation of 1-(2, 3, 4-trimethoxyphenyl)-2-substituted heterocyclic thio ethanone derivatives was achieved by the reactions of mercapto compounds with 2-bromo-1-(2, 3, 4-trimethoxyphenyl) ethanone in water mediated by indium in very high yields. Antifungal activities of the compounds were examined and moderate activity was obtained.

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2007年05月22日

【期刊论文】Indium Trichloride-Mediated Facile Synthesis of 3-(Substituted methylthio)-4-phenyl-5-(3, 4, 5-trimethoxyphenyl)-4H-1, 2, 4-triazole in Water†

杨松， YANG Song， LIU， Jie， SONG， Bao-An， JIN， Lin-Hong， HU， De-Yu

Chinese Journal of Chemistry, 2006, 24, 1263-1266，-0001，（）：

-1年11月30日

摘要

An environmentally benign and efficient process for the preparation of 3-(substituted methylthio)-4-phenyl-5-(3, 4, 5-trimethoxyphenyl)-4H-1, 2, 4-triazole was achieved by the reaction of 4-phenyl-5-(3, 4, 5-trimethoxyphenyl)-4H-1, 2, 4-triazole-3-thiol with different halides in aqueous media mediated by indium trichloride in high yields.

thioether， 1,， 2,， 4-triazole， indium trichloride， synthesis

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2007年05月22日

【期刊论文】Synthesis and bioactivity of 4-alkyl (aryl) thioquinazoline derivatives

杨松， Song Yang， Zhi Li， Linhong Jin， Baoan Song， Gang Liu， Jiang Chen， Zhuo Chen， Deyu Hu， Wei Xue and Ruiqing Xu

S. Yang et al. Bioorg. Med. Chem. Lett. 17 (2007) 2193-2196，-0001，（）：

-1年11月30日

摘要

Some S'-substituted 4-alkyl (aryl) thioquinazoline derivatives were synthesized through thioetherification reaction of 4-chloroquinazolines 2 and thiol compounds 1 refluxed in acetone in the presence of K2CO3. Their structures were verified by elemental analysis, IR, 1H NMR, and 13C NMR. The compounds were evaluated for their anti-proliferative activities against some cancer cells in vitro by MTT method. Among them, 3c, 3a, 3d, 3f, and 3l were highly effective against PC3 cells and 3a-3m showed weak activities against Bcap37 and BGC823 cells. The IC50 value of 3c, 3a, 3d, 3f, and3l against PC3 cell was 1. 8, 5. 6, 8. 1, 8. 7, and 8. 9 μM, respectively.

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