中国科技论文在线

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2005年03月04日

【期刊论文】DIBAL-H-H2NR and DIBAL-H-HNR1R2

黄培强， Pei-Qiang Huang， * Xiao Zheng and Xian-Ming Deng

Tetrahedron Letters 42(2001)9039-9041，-0001，（）：

-1年11月30日

摘要

The reaction of a lactone or an ester with organoaluminum species generated from DIBAL-H-H2NR or DIBAL-H-HNR1R2

aminolysis， DIBAL-H， Weinreb amides， amides.，

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2005年03月04日

【期刊论文】Asymmetric Synthesis of Antimalarial Alkaloids (+)-Febrifugine and(+)-Isofebrifugine

黄培强， Pei-Qiang Huang， * Bang-Guo Wei， Yuan-Ping Ruan

Synlett 2003, No. 11, 1663-1667，-0001，（）：

-1年11月30日

摘要

Diastereoselective a-amidoalkylation of N,O-acetal, derivated from controlled regio and diastereoselective reduction of (S)-N-(4-methoxybenzyl)-3-silyloxyglutarimide provided two diastereomeric 6-allyl-5-silyloxy-2-piperidinones in 76:24 selectivity. The transformation of the major diastereomer into a known advanced intermediate allowed the synthesis of (+)-febrifugine and (+)-isofebrifugine.

piperidines,， alkaloids,， allylations,， N,， O-acetal,， asymmetric synthesis

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2005年03月04日

【期刊论文】A versatile approach for the asymmetric synthesis of 3-alkyl-2,3-dihydro-1H-isoindolin-1-ones

黄培强， Ming-De Chen， Xiang Zhou， Ming-Zhu He， Yuan-Ping Ruan and Pei-Qiang Huang*

Tetrahedron 60(2004)1651-1657，-0001，（）：

-1年11月30日

摘要

Based on the use of (R)-p-benzyloxyphenylglycinol (10) as a new oxidatively cleavable chiral auxiliary, a flexible approach to (R)-3-alkyl-2,3-dihydro-1H-isoindolin-1-ones via a diastereoselective reductive-alkylation is developed. The oxidative cleavage of the chiral auxiliary by CAN under mild conditions ensured the access to (R)-3-alkyl-2,3-dihydro-1H-isoindolin-1-ones with ee at least 92%.

Isoindolin-1-one， Chiral auxiliary， Benzyloxyphenylglycinol， Asymmetric synthesis.，

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2005年03月04日

【期刊论文】A Flexible Approach for the Asymmetric Synthesis of N-Protected (R)-5-Alkyl Tetramates and (R)-5-Alkyl Tetramic Acid Derivatives

黄培强， Pei-Qiang Huang， * Jun Deng

Synlett 2004, No. 2, 247-250，-0001，（）：

-1年11月30日

摘要

A flexible two-step asymmetric approach to N-protected (R)-5-alkyl tetramates and (R)-5-alkyl tetramic acid derivatives is described. The method is based on the diastereoselective alkylation of (R)-phenylglycinol derived tetramates 7 and 8, which are the first synthetic equivalents to chiral nonracemic tetramate 5-carbanionic synthons A.

asymmetric synthesis,， alkylations,， chiral auxiliaries,， tetramates,， tetramic acids

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2005年03月04日

【期刊论文】A flexible non-amino acid-based formal asymmetric synthesis of naturally occurring (2R,3S)-2-aminotetradeca-5,7-dien-3-ol: observation of a remarkable protecting group effect

黄培强， Bi-Yan He， Tian-Jun Wu， Xian-Yong Yu and Pei-Qiang Huang*

Tetrahedron: Asymmentry 14(2003)2101-2108，-0001，（）：

-1年11月30日

摘要

A flexible non-amino acid-based formal asymmetric synthesis of naturally occurring antimicrobial (2R,3S)-2-aminotetradeca-5,7-dien-3-ol is reported. The method features a flexible and highly regioselective Grignard addition to (S)-malimide followed by a trans-diastereoselective reductive deoxygenation. The scope and limitations of the highly regio and diastereoselective reductive alkylation of malimides were defined. A remarkable protecting group effect on the regio and diastereoselective reductive alkylation of malimides was observed.

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