A clinical and laboratory analyrsis of the dYnamlc change of plasma cortisol level in tw0 groups of chiIdren with neDhrotic syndrome has been made-a combined treatment group and a control group. The former was given long-term large dosage prednisone co rnbined with "Z1 Yin Jiailg Huo" and "Wen Bu Shen Yang" drugs, while the latter received no traditionaI medieine during pred-nisone administration The aim of the present study is to find Out whether tra-ditional medicines can protect the adrenal cortex. and antagonize the negative feed-back action Of exogenous steroid, thereby providing a theoretical and labora tory basis for dinical use of traditional medicines in reducing severe side effects of large dosage of steroid. Our results show: 1. Large dosage prednisone, either given daily in diVided doses or once every other day, can significantly suppress the adrenocortical activity, and the suppressive action decreases along with taper-ing off of the dosage of prednisone. 2. "Wen Bu Shen Yang" drugs can remark ably protect the adrenal eortex and antagonize the negative feed-back action of exogenous glucocorticosteroid. 3. "Zi Yin Jiang Huo" drugs possess no significant influence on plasma cortisoI level during long-term large dosage steroid therapy.

本文检测了四种先天性心肚病患儿各9例矫活手术前后的血浆皮质醇。结果表明患儿肾上腺皮质在术后出现了强烈的应激反应，直至术后七口尚未完全恢复，且血浆皮质醇升高的程度与机体对手术应激反应的强度密切栩关。据此并结合对术后并发症发生率及激素使用情况的分析，认为对于大多数施行体外循环的先心病患儿，木中、术后不宜常规预防性地应用皮质激素药物。

我们测定了42例单纯性肥胖症小儿的肾上腺皮质功能，结果显示：①1/3的患儿血浆总皮质醇(PTC)昼夜节律正常，而其余2/3的患儿存在不同程度、不同类型的异常；②展游离皮质醇(UFC)的含量在正常范围；③地塞米辁抑制筛查试验正常。表明多数单纯性肥胖症患儿的肾上腺皮质功能活动水平较高，但对地塞米松的反馈抑制作月仍十分敏感，与正常小儿及柯兴综台征患者均有显著不同。

对处于青春发育不同阶段的57例女性特发性真性性早熟患儿进行了下丘脑-垂体-卵巢轴功能及子宫卵巢容积的测定，并将各项指标与性早熟的程度做相关分析，结果表明：（1）性早熟的程度与患儿的病程长短、骨骼生长加速的程度、子宫卵巢容积大小以及下丘脑-垂体-卵巢轴功能亢进的程度密切相关，而与起病年龄无关；（2）特发性性早熟患儿的下丘脑-垂体-卵巢轴提前发动，功能亢进。其GnRH兴奋试验的反应曲线具有特征性的改变；（3）特发性性早熟患儿与正常青春发育相比，其内生殖器官的发育较不成熟，体积相对较小。