中国科技论文在线

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2005年07月13日

【期刊论文】Sesquiterpene polyol esters from Tripterygium wilfordii

段宏泉， Hong-Quan Duan a， Yoshihisa Takaishi a， *， Yong-Feng Jia b， Duan Li b

Phytochemistry 56(2001)341～346，-0001，（）：

-1年11月30日

The extract (TII) of Tripterygium wilfordiiHook f. afforded four sesquiterpene esters: 1β, 2β,5a, 8β,11-pentaacetoxy-4a-hydroxy-3a(2'-methylbutanoyl)-15-nicotinoyl-7-oxo-dihydroagarofuran; 1β,5a,11-triacetoxy-7β-benzoyl-4a-hydroxy-8+-nicotinoyl-dihydroagarofuran;1β,2β,5a,11-tetraacetoxy-8a-benzoyl-4a-hydroxy-7β-nicotinoyl-dihydroagarofuran; 5a-benzoyl-4a-hydroxy-1β,8a -dinicotinoyl-dihydro-agarofuran as well as one other known sesquiterpene ester. Their structures were established on the basis of spectroscopic studies.

Tripterygium wilfordii， Celastraceae， TII， Sesquiterpene esters

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2005年07月13日

【期刊论文】Immunosuppressive Sesquiterpene Alkaloids from Tripterygium wilfordii

段宏泉， Hongquan Duan， † Yoshihisa Takaishi， *， † Hiroshi Momota， ‡ Yasukazu Ohmoto， ‡ Takao Taki， ‡ Yongfeng Jia， § and Duan Li§

J. Nat. Prod. 2001, 64, 582～587，-0001，（）：

-1年11月30日

摘要

Nine new sesquiterpene pyridine alkaloids [wilfornines A (1), B (2), C (3), D (4), E (5), F (8), and G (9); wilfordinines I (6) and J (7)] and six known compounds (10-15) were isolated from a clinically used extract (TII) of Tripterygium wilfordii. The structures of 1-9 were elucidated by spectroscopic and chemical methods. The inhibitory effects on cytokine production of 1-3 and several related compounds were evaluated. Compounds 10 and 14 showed significant inhibitory effects on cytokine production.

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2005年07月13日

【期刊论文】Immunosuppressive constituents from Saussurea medusa

段宏泉， Hongquan Duan a， Yoshihisa Takaishi a， *， Hiroshi Momota b， Yasukazu Ohmoto b， Takao Taki b

Phytochemistry 59(2002)85～90，-0001，（）：

-1年11月30日

摘要

The methanol extract of Saussurea medusa Maxim afforded two lignans: 2a-guaicyl-4-oxo-6a-catechyl-3,7-dioxabicyclo [3.3.0]octane and 1a-hydroxy-2a,4a-guaicyl-3,7-dioxabicyclo[3.3.0]octane; two chlorophyll derivatives: 13-epi-phaeophorbide-a and 13-epi-phaeophorbide-a methyl ester; one megastigmane derivative: 3b-hydroxy-5a,6a-epoxy-7-megastigmen-9-one, along with 19 known compounds. Their structures were established on the basis of spectroscopic studies.

Saussurea medusa， Compositae， Lignan， Phaeophorbide， Immunosuppressive activity

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2005年07月13日

【期刊论文】Immunosuppressive terpenoids from extracts of Tripterygium wilfordii

段宏泉， Hongquan Duan， a， Yoshihisa Takaishi， *， Hiroshi Momota， b， Yasukazu Ohmotoo， Takao Taki， Motoo Tori， c， Shigeru Takaoka， Yongfeng Jia， d， and Duan Lid

Tetrahedron 57(2001)8413～8424，-0001，（）：

-1年11月30日

摘要

The dlinically uded extract (TⅡ) of Tripterygium wilfordii Hook f. give 19 new compounds, including five kaurane diterpenes (1-5), one manoyl oxide diterpene (6), and one abietane diterpene (7), three ursene triterpenes (8,9and15), six oleanane triterpenes (10-13,16and19), and three friedelane triterpenes (14, 17and18), as well ad 15 known compounds (20-34). Their structures were elucidated by spectroscopy and X-ray analysis. Based on the screening of isolated compounds and other compounds reported in previous papers [J. Nat. Prod. 62 (1999) 1522; J. Nat. Prod. (2001) in press; Phytochemistry 53 (2000) 805], we identified the main components that are responsible for the therapeutic effect of TⅡ.

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2005年07月13日

【期刊论文】Chemical Constituents from the Colombian Medicinal Plant Niphogeton ternata

段宏泉， Hongquan DUAN， a， Yoshihisa TAKAISHI， *， Yoshinori FUJIMOTO， b， Cristina GARZON， e， Coralia OSORIO， d， and Carmenza DUOUI

Chem. Pharm. Bull. 50(1)115～117 (2002)，-0001，（）：

-1年11月30日

摘要

Two eoumarins and one polyaeetylene, 5-O-(3-chloro-2-hydroxy-3-methylbutyl)-8-methoxypsoralen (1), 2', 3' -dihydro-jatamansin (2), and 10-chloro-1-heptadecene-4.6-diyne-3,8,9-triol (3), along with 15 known compounds (4-18), were isolated from the methanol extract of Niphogeton ternata. Their struetures were elucidated by spectroseopy.

Niphogeton termata， Umbelliferae， coumarin， polyacetylene

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