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2005年07月13日

【期刊论文】SESQUITERPENE ALKALOIDS FROM TRIPTER YGIUM HYPOGLA UCUM

段宏泉， HONGQUAN DUAN， KAZUYOSHI KAWAZOE and YOSHIHSA TAKAISHI*

Phytochemistry, Vol. 45, No.3, pp. 617～621, 1997，-0001，（）：

-1年11月30日

Esters of three new (hyponines A-C) and four known sesquiterpene polyalcohol esters have been isolated from the root bark of Tripterygium hypoglaucum. The structures of the new compounds were elucidated at 7-(acetyloxy)-OS-furanoyl-OS-deacetyl-7-deoxo-evonine, 7-(acetyloxy)-O11-furanoyl-O11-deacetyl-7-deoxo-evonine and 7-(acetyloxy)-O11-benzoyl-O11-deacetyl-7-deoxo-evonine by spectroscopic means. This structural elucidation indicated that the structure of the known compound should be reversed.

Index-Tripterygium hypoglaucum， Celastraceae， root bark， sesquiterpenes， alka-loids， evonine， hyponine.，

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2005年07月13日

【期刊论文】Immunosuppressive constituents from Saussurea medusa

段宏泉， Hongquan Duan a， Yoshihisa Takaishi a， *， Hiroshi Momota b， Yasukazu Ohmoto b， Takao Taki b

Phytochemistry 59(2002)85～90，-0001，（）：

-1年11月30日

摘要

The methanol extract of Saussurea medusa Maxim afforded two lignans: 2a-guaicyl-4-oxo-6a-catechyl-3,7-dioxabicyclo [3.3.0]octane and 1a-hydroxy-2a,4a-guaicyl-3,7-dioxabicyclo[3.3.0]octane; two chlorophyll derivatives: 13-epi-phaeophorbide-a and 13-epi-phaeophorbide-a methyl ester; one megastigmane derivative: 3b-hydroxy-5a,6a-epoxy-7-megastigmen-9-one, along with 19 known compounds. Their structures were established on the basis of spectroscopic studies.

Saussurea medusa， Compositae， Lignan， Phaeophorbide， Immunosuppressive activity

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2005年07月13日

【期刊论文】DI- AND TRITERPENOIDS FROM TRIPTER YGIUM HYPOGLA UCUM

段宏泉， HONGQUAN DUAN， KAZUYOSHI KAWAZOE， MASAHIKO BANDO*， MASARU K]DO* and YOSHIHISA TAKAISHI†

Ph.vtochemistry, Vol. 46, No.3, pp. 535～543, 1997，-0001，（）：

-1年11月30日

摘要

The methanol extract of dried root outer bark of Tripterygium hypoglaucum (Levl.) Hutch afforded five new triterpenes: 2,3-seco-2,24-epoxy-D:A-friedoolenane-2, 24-olide-29-oic acid named celastolide, 2,23-dihydroxy-3-methoxy-6-oxo-l,3,5(10), 8-tetraene-24-nor-D:A-friedoolenane-29-oic acid, 2-hydroxy-3-methoxy-6-oxo-l,3,5(10), 8-tetraene-24-nor-D:A-friedoolenane-29-oic acid, 2,3-dihydroxy-l,3,5(10), 8-tetraene-24-nor-D: A-friedoolenane-29-oic acid and 3fl, 11 e-dihydroxy- 13(18)-ene-oleanane named triptohypol A, B and C and hypodiol, and two new diterpenes: 3/3,14,19-trihydroxy-abieta-8,11,13-triene and 7-oxo-I 1,13-dihydroxy- 19(4-3)-abeo-abieta-3,8,11,13-tetraene-19,18-olide named triptobenzene J and K. and 18 known compounds. Their structures were established on the basis of chemical and spectroscopic studies.

Tripterygium hypoglaucum， Celastraceae， triterpene， diterpene: celastolide， triptohypol， hypodiol.，

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2005年07月13日

【期刊论文】Sesquiterpene evoninate alkaloids from Tripterygium hypoglaucum

段宏泉， Hongquan Duan， Yoshihisa Takaishi*

Phytochemistry 52(1999)1735～1738，-0001，（）：

-1年11月30日

摘要

Esters of three new (hyponines D

Tripterygium hypoglaucum， Celastraceae， Root bark， Sesquiterpenes， Pyridine alkaloids， Hyponine

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2005年07月13日

【期刊论文】Novel Sesquiterpene Esters with Alkaloid and Monoterpene and Related Compounds from Tripterygium Hypoglaucum：A New Class of Potent Anti-HIV Agents

段宏泉， Hongquan Duan a， Yoshihisa Takaishti a* Masahiko Bando b Masaru Kido b， Yasuo Imakura c and KuoHsiung Lee d

Tetrahedron Letters 40(1999)2969～2972，-0001，（）：

-1年11月30日

摘要

Two new sesquiterpene polyol esters (triptonine A and B) with alkaloid and monoterpene were isolated from Tripterygium hypoglaucum (Levi.) Hutch. Their structures were elucidated by spectroscopic means and X-ray analysis. Triptonine A (1) and hypoglaunine B3) (4) demonstrated potent anti-HIV activity with EC50 values of 2.54 and 0.13

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