中国科技论文在线

上传时间

2005年07月13日

【期刊论文】Immunosuppressive Sesquiterpene Alkaloids from Tripterygium wilfordii

段宏泉， Hongquan Duan， † Yoshihisa Takaishi， *， † Hiroshi Momota， ‡ Yasukazu Ohmoto， ‡ Takao Taki， ‡ Yongfeng Jia， § and Duan Li§

J. Nat. Prod. 2001, 64, 582～587，-0001，（）：

-1年11月30日

摘要

Nine new sesquiterpene pyridine alkaloids [wilfornines A (1), B (2), C (3), D (4), E (5), F (8), and G (9); wilfordinines I (6) and J (7)] and six known compounds (10-15) were isolated from a clinically used extract (TII) of Tripterygium wilfordii. The structures of 1-9 were elucidated by spectroscopic and chemical methods. The inhibitory effects on cytokine production of 1-3 and several related compounds were evaluated. Compounds 10 and 14 showed significant inhibitory effects on cytokine production.

36浏览
0点赞
0收藏
0分享
92下载
0

引用

上传时间

2005年07月13日

【期刊论文】SESQUITERPENE ALKALOIDS FROM TRIPTER YGIUM HYPOGLA UCUM

段宏泉， HONGQUAN DUAN， KAZUYOSHI KAWAZOE and YOSHIHSA TAKAISHI*

Phytochemistry, Vol. 45, No.3, pp. 617～621, 1997，-0001，（）：

-1年11月30日

摘要

Esters of three new (hyponines A-C) and four known sesquiterpene polyalcohol esters have been isolated from the root bark of Tripterygium hypoglaucum. The structures of the new compounds were elucidated at 7-(acetyloxy)-OS-furanoyl-OS-deacetyl-7-deoxo-evonine, 7-(acetyloxy)-O11-furanoyl-O11-deacetyl-7-deoxo-evonine and 7-(acetyloxy)-O11-benzoyl-O11-deacetyl-7-deoxo-evonine by spectroscopic means. This structural elucidation indicated that the structure of the known compound should be reversed.

Index-Tripterygium hypoglaucum， Celastraceae， root bark， sesquiterpenes， alka-loids， evonine， hyponine.，

107浏览
0点赞
0收藏
0分享
85下载
0

引用

上传时间

2005年07月13日

【期刊论文】DI- AND TRITERPENOIDS FROM TRIPTER YGIUM HYPOGLA UCUM

段宏泉， HONGQUAN DUAN， KAZUYOSHI KAWAZOE， MASAHIKO BANDO*， MASARU K]DO* and YOSHIHISA TAKAISHI†

Ph.vtochemistry, Vol. 46, No.3, pp. 535～543, 1997，-0001，（）：

-1年11月30日

摘要

The methanol extract of dried root outer bark of Tripterygium hypoglaucum (Levl.) Hutch afforded five new triterpenes: 2,3-seco-2,24-epoxy-D:A-friedoolenane-2, 24-olide-29-oic acid named celastolide, 2,23-dihydroxy-3-methoxy-6-oxo-l,3,5(10), 8-tetraene-24-nor-D:A-friedoolenane-29-oic acid, 2-hydroxy-3-methoxy-6-oxo-l,3,5(10), 8-tetraene-24-nor-D:A-friedoolenane-29-oic acid, 2,3-dihydroxy-l,3,5(10), 8-tetraene-24-nor-D: A-friedoolenane-29-oic acid and 3fl, 11 e-dihydroxy- 13(18)-ene-oleanane named triptohypol A, B and C and hypodiol, and two new diterpenes: 3/3,14,19-trihydroxy-abieta-8,11,13-triene and 7-oxo-I 1,13-dihydroxy- 19(4-3)-abeo-abieta-3,8,11,13-tetraene-19,18-olide named triptobenzene J and K. and 18 known compounds. Their structures were established on the basis of chemical and spectroscopic studies.

Tripterygium hypoglaucum， Celastraceae， triterpene， diterpene: celastolide， triptohypol， hypodiol.，