We have analyzed cardiac ische. mia-reperfusion in an animal model using epicardial electrODOtenlial mapping. We investigated the rela. tionship between ischemia and variability of multifractality in epicardial electrograms. We present a new parameter called the singularity spectrum area reference dispersion (SARD) that clearly demon. strates the change in multifractility with the extent of myocardiaischemia. By contrasting the 3D ventricular epicardial SARD map with the activation map, we conclude that myocardiaI ischemia significantly influences the variety of multifractality of ventricular epicardium electrograms and the SARD parameter is usefuIin correlating multifractality of epicardiaI elec. trograms with Iocation of ischemia closely.