Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis，成果详细信息-中国科技论文在线

周虎臣

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Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis

周虎臣， Tsutomu Akama * ， Stephen J. Baker ， Yong-Kang Zhang ， Vincent Hernandez ， Huchen Zhou ， Virginia Sanders ， Yvonne Freund ， Richard Kimura ， Kirk R. Maples ， Jacob J. Plattner

Bioorganic & Medicinal Chemistry Letters 19(2009)2129-2132，-0001，（）：

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摘要/描述

A series of phenoxy benzoxaboroles were synthesized and screened for their inhibitory activity against PDE4 and cytokine release. 5-(4-Cyanophenoxy)-2,3-dihydro-1-hydroxy-2,1-benzoxaborole (AN2728) showed potent activity both in vitro and in vivo. This compound is now in clinical development for the topical treatment of psoriasis and being pursued for the topical treatment of atopic dermatitis.

关键词: Anti-inflammatory Phosphodiesterase Oxaborole Psoriasis Atopic dermatitis

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