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郭子建
主要的研究方向为生物无机化学，研究内容包括：1）金属药物的设计及作用机理研究：新型含铂、金、钌等抗癌配合物的设计及生物活性；临床药物与生物分子的相互作用等；2）金属人工核酸酶的设计及应用：含铜、锌等金属配合物在核酸识别与切割中的应用；3）生物锌离子荧光探针的设计与构筑。
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- 姓名：郭子建
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学术头衔：
博士生导师， 国家杰出青年科学基金获得者
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学科领域：
无机化学
- 研究兴趣：主要的研究方向为生物无机化学，研究内容包括：1）金属药物的设计及作用机理研究：新型含铂、金、钌等抗癌配合物的设计及生物活性；临床药物与生物分子的相互作用等；2）金属人工核酸酶的设计及应用：含铜、锌等金属配合物在核酸识别与切割中的应用；3）生物锌离子荧光探针的设计与构筑。
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2009-01-13
【期刊论文】Disulfide Bond Cleavage Induced by a Platinum(II) Methionine Complex
郭子建， Haiying Wei， † Xiaoyong Wang， † Qin Liu， †， ‡ Yuhua Mei， † Yi Lu， § and Zijian Guo*
Inorganic Chemistry, Vol. 44, No.17, 2005, 6077，-0001，（）：
-1年11月30日
The cleavage of a disulfide bond and the redox equilibrium of thiol/disulfide are strongly related to the levels of glutathione (GSH)/oxidized glutathione (GSSG) or mixed disulfides in vivo. In this work, the cleavage of a disulfide bond in GSSG induced by a platinum(II) complex [Pt(Met)Cl2] (where Met ) methionine) was studied and the cleavage fragments or their platinated adducts were identified by means of electrospray mass spectrometry, highperformance liquid chromatography, and ultraviolet techniques. The second-order rate constant for the reaction between [Pt(Met)Cl2] and GSSG was determined to be 0.4M-1 s-1 at 310K and pH 7.4, which is 100- and 12-fold faster than those of cisplatin and its monoaqua species, respectively. Different complexes were formed in the reaction of [Pt(Met)Cl2] with GSSG, mainly mono- and dinuclear platinum complexes with the cleavage fragments of GSSG. This study demonstrated that [Pt(Met)Cl2] can promote the cleavage of disulfide bonds. The mechanistic insight obtained from this study may provide a deeper understanding on the potential involvement of platinum complexes in the intracellular GSH/GSSG systems.
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