Purpose: Although much has been written about the role of the NMDA receptor’s role in experience dependent visual plasticity, the function of the NMDAR1 receptor subunit in the post-plasticity stage of development is still not well understood. However, in the well studied model of strabismic amblyopia where binocularity is reduced, but where most primary visual cortex neurons can be driven by one or other eye, the density of expression of NMDAR1 receptor protein is significantly reduced, compared to normals. This study aims to identify which of eight isoforms of the spliced heterogeneous variants of the NMDAR1 mRNA receptor gene are associated with this decrease in expression as a means of elucidating possible function.

儿童严重屈光参差患者的弱视发生率高达66.67%，其中28.30%患儿终致视力残疾。近十年准分子激光手术矫治儿童严重屈光参差的研究表明，该手术是安全、有效的，可预测性及稳定性均较好，为儿童屈光参差性弱视治疗提供了一个良好的条件。术后进行规范的弱视治疗，提高了治愈率，降低了致残率。然而，儿童屈光手术矫治起始年龄、等值球镜的矫治范围、术后角膜剩余厚度等有待规范。术后儿童角膜修复机制的研究有待深入。