叶文才
长期从事中药及天然药物的化学成分(尤其对皂苷类成分)研究。
个性化签名
- 姓名:叶文才
- 目前身份:
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- 学位:
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学术头衔:
博士生导师, 优秀教师/优秀教育工作者
- 职称:-
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学科领域:
中药学
- 研究兴趣:长期从事中药及天然药物的化学成分(尤其对皂苷类成分)研究。
叶文才,男,1962年6月出生,安徽歙县人。1983年毕业于南京药学院中药专业获理学学士学位; 1983年 ~ 1988年在安徽芜湖中医学校任教; 1988年底始在中国药科大学天然药物化学教研室工作,1995年任副教授、硕士生导师。1997年~ 2001年在香港科技大学化学系学习,获博士学位。2001年任中国药科大学教授、博士生导师、校学位委员会委员; 2003年任暨南大学中药及天然药物研究所常务副所长、博士生导师、一级特聘教授。为教育部优秀青年教师资助计划及江苏省333新世纪学术带头人培养工程入选者,2003年度中国药学发展奖(地奥)中药奖三等奖获得者,广东省药学会药物化学专业委员会副主任委员,《中国药科大学学报》、《中国医学生物技术研究应用》等杂志编委,欧洲肿瘤研究学会(EACR)等学会会员。
长期从事中药及天然药物的化学成分(尤其对皂苷类成分)研究, 在对30余种药用植物的活性成分研究过程中,发现了150余种新化合物、4种新骨架结构成分及一些重要的新药先导化合物。此外,还揭示了C-3和C-28双糖链三萜皂苷串联电子喷雾质谱(ESI-MSn)的重要裂解规律,并在药用活性物质的构效关系、药用植物化学系统学和生态学、天然药物研究成果转化方面取得了一定成绩。
主持了包括国家自然科学基金、国家“十五”重大科技专项(863项目)、国家“九五”重点科技攻关、国家新药研究基金、广东省关键领域重大突破项目在内的各类科研项目16项, 另作为主要完成人参加项目8项。已发表研究论文120余篇(其中在被SCI收录的国际权威杂志上发表论文50余篇,被引用140余次)、申请发明专利10项 (其中6项已授权)、参编著作7部, 获国家科技进步二等奖和国家中药二类新药临床批件各1项。在教学工作中,讲授了1门本科生和3门研究生课程;指导硕士、博士研究生共41名,己毕业10名,在读31名。毕业的研究生中,1名博士生和1名硕士生的毕业论文获省级优秀论文。
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455
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成果数
10
叶文才, Chang-Xin Zhou, a, Jun-Yan Liu, Wen-Cai Ye, b, Chang-Hong Liu a and Ren-Xiang Tan a, *
Tetrahedron 59 (2003) 5743-5747,-0001,():
-1年11月30日
Bioassay-guided fractionation of the ethanol extract of the roots and rhizomes of Veratrum taliense yielded two new and thirteen known steroidal alkaloids. The structures of the two new compounds, neoverataline A and B, were established by extensive spectroscopic analyses to be 3,4-secocevane-4, 9-olid-14,15,16,20-tetra-ol-3-oic acid and 3, 4-secocevane-4, 9-olid-7, 14, 15, 16, 20-penta-ol-3-oic acid, respectively, and are a novel carbon skelton. All of the fifteen alkaloids were subjected to in vitro antifungal assays, which showed that the verazine- (veramitaline, stenophylline B, stenophylline B-3-O-b-D-glucopyranoside, veramiline-3-O-b-D glucopyranoside) and jerveratrum- type (jervine, jervine-3-O-b-D-glucopyranoside) alkaloids exhibited strong antifungal activities against the phytopathogenic fungus Phytophthora capisis with MICs of 160, 120, 160, 80, 80 and 120mg·L21, respectively. Furthermore, the verazine-type alkaloids stenophylline B, stenophylline B 3-O-b-D-glucopyranoside and veramiline 3-O-b-D-glucopyranoside were shown to also inhibit the growth of another fungal phytopathogen Rhizoctonia cerealis with MICs of 160, 120 and 120mg mL21. The MICs of triadimefon (an antifungal agrochemical used herein as a positive control) against P. capisis and R. cerealis were 120 and 80mg mL21, respectively. A preliminary structure–activity relationship regarding these alkaloids has been formulated.
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叶文才, Ren-Wang Jiang, a, Po-Ming Hon, b, Paul Pui-Hay But, Hoi-Sing Chung, c, Ge Lin, Wen-Cai Ye d and Thomas C. W. Mak a, *
Tetrahedron 58 (2002) 6705-6712,-0001,():
-1年11月30日
Two new stenine-type alkaloids, neotuberostemonol (3) and neotuberostemoninol (4), along with the known compound neotuberostemonine (2), were isolated from Stemona tuberosa Lour. Their structures were characterized by X-ray crystallography in combination with spectroscopic methods, and their absolute configurations were inferred from the known configuration of tuberostemonine (1). In the crystalline state, weak C-H O hydrogen bonds play an important role in the molecular packing of 3 and 4. q 2002 Elsevier Science Ltd. All rights reserved.
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【期刊论文】Isoquinoline and isoindole alkaloids from Menispermum dauricum
叶文才, Xiaoqi Zhang a, Wencai Ye a, Shouxun Zhao a, Chun-Tao Che b, *
Phytochemistry 65 (2004) 929-932,-0001,():
-1年11月30日
Three isoquinoline alkaloids and an isoindole alkaloid, along with eight known compounds, were isolated from the roots of Menispermum dauricum (Menispermacese). The alkaloids were characterized as 7-hydroxy-6-methoxy-1(2H)-isoquinolinone, 6,7- dimethoxy-N-methyl-3,4-dioxo-1(2H)-isoquinolinone, 1-(4-hydroxybenzoyl)-7-hydroxy-6-methoxy-isoquinoline and 6-hydroxy-5-methoxy-N-methylphthalimide, on the basis of spectral evidence including 1D-and 2D-NMR and MS analyses.
Menispermum dauricum, Menispermaceae, Isoquinoline, Isoindole, Alkaloids
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【期刊论文】Two new flavonol glycosides from Gymnema sylvestre and Euphorbia ebracteolata
叶文才, Xin Liu, a, b, Wencai Ye, *, Biao Yu, Shouxun Zhao, Houming Wu a and Chuntao Che
Carbohydrate Research 339 (2004) 891-895,-0001,():
-1年11月30日
Two new flavonol glycosides, namely kaempferol 3-O-b-D-glucopyranosyl-(1fi4)-a-L-rhamnopyranosyl-(1fi6)-b-Dgalactopyranoside (1) and quercetin 3-O-600-(3-hydroxyl-3-methylglutaryl)-b-D-glucopyranoside (2), have been isolated from the aerial parts of Gymnema sylvestre and Euphorbia ebracteolata, respectively. Their structures were determined on the basis of chemical and spectroscopic methods.
Flavonol glycoside, Kaempferol 3-O-b-D-glucopyranosyl-(, 1fi4), -a-L rhamnopyranosyl-(, 1fi6), -b-D-galactopyranoside, Quercetin 3-O-600-(, 3-hydroxyl-3-methylglutaryl), -b-D-glucopyranoside, Gymnema sylvestre, Euphorbia ebracteolata
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【期刊论文】Three New Cyclopentanoid Monoterpenes from Picrorhiza scropulariiflora
叶文才, Hao Wang, Wen Cai Ye. Ren Wang Jiang, jia-jun Wu, Thomas W. Mak, Shou xun Zhao, Xin Sheng Yao.
Plant Med 2004; 2004; 70: 382-384,-0001,():
-1年11月30日
Three new cycloDentanold monoterpenes namecl piscrocins A (1) B (2)antl (3) were lsolateclcom the roots of Pic~orhnd sctophulariiflora (scrophulariaceae). The structures ofthese new compounds were establishecl by 1D antl 2D NMR spectroscopic techniques (HHCOSY, HMQC, HMBC, antl NOESY) In combination with X ray clystallographic analysis
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【期刊论文】TRITERPENOIDS FROM PULSATILLA CHINENSIS
叶文才, WEN-CAI YE*, NINE-NING JI, SHOU-XUN ZHAO, JING-HAN LIO, TAO YE, *†‡ M. A. MCKERVEY† and E STEVENSON†
Phytochemistry, Vol. 42, No.3, pp. 799-802, 1996,-0001,():
-1年11月30日
A new lupane type triterpenic acid, pulsatillic acid, and two new lupane type triterpenoid glycosides, pulsatiUoside A and B, along with the known 23-hydroxybetulinic acid were isolated from the roots of Pulsatilla chinensis. Their structures were characterized as 3-oxo-23-hydroxy-lup-20(29)-en-28-oic acid, 3fl, 23-dihydroxy-lup-20(29)-en-28-oic acid 3-O-a-L-arabinopyranoside and 3/3, 23-dihydroxy-lup-20(29)-en-28-oic acid 28-0-/3-0- glucopyranosyl-(1-6)-/3-o-glucopyranoside on the basis of hydrolysis and spectral evidence including two-dimensional relay HOHAHA, one-dimensional multiple relay COSY and ROESY NMR techniques. Pulsatillic acid exhibited cytotoxic activities against P-388, Lewis lung carcinoma and human large-cell lung carcinoma.
Pulsatilla chinensis, Ranunculaceae, triterpenic acid, triterpenoid glycosides, 23-hydroxybetulinic acid, pulsatillic acid, pulsatilloside A and B.,
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【期刊论文】New Lupane Glycosides from Pulsatilla chinensis
叶文才, Wencai ye, Qingwen Zhang, Wendy W. L.Hsiao, Shouun Zhao. Chun-Tao Che
Planta Med2002; 68: 183-186,-0001,():
-1年11月30日
A new lupane type triterpenic acid, pulsatillic acid, and two new lupane type triterpenoid glycosides, pulsati Uoside A and B, along with the known 23-hydroxybetulinic acid were isolated from the roots of Pulsatilla chinensis. Their structures were characterized as 3-oxo-23-hydroxy-lup-20(29)-en-28-oic acid, 3fl, 23-dihydroxy-lup-20(29)-en-28-oic acid 3-O-a-L-arabinopyranoside and 3/3, 23-dihydroxy-lup-20(29)-en-28-oic acid 28-0-/3-0- glucopyranosyl-(1-6)-/3-o-glucopyranoside on the basis of hydrolysis and spectral evidence including two-dimensional relay HOHAHA, one-dimensional multiple relay COSY and ROESY NMR techniques. Pulsatillic acid exhibited cytotoxic activities against P-388, Lewis lung carcinoma and human large-cell lung carcinoma.
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【期刊论文】Oleanane saponins from Gymnema sylvestre
叶文才, Wen-Cai Ye a, b, Qing-Wen Zhang b, Xin Liu b, Chun-Tao Che a, c, *, Shou-Xun Zhao
Phytochemistry 53 (2000) 893-899,-0001,():
-1年11月30日
Six oleanane-type saponins, along with two known triterpene saponins, were isolated from the leaves of Gymnema sylvestre. The structures of the oleanane triterpene glycosides were characterized as longispinogenin 3-O-b-D-glucuronopyranoside, 21b-benzoylsitakisogenin 3-O-b-D-glucuronopyranoside, 3-O-b-D-glucopyranosyl(146)-b-D-glucopyranosyl oleanolic acid 28-O-b-D- glucopyranosyl ester, oleanolic acid 3-O-b-D-xylopyranosyl(146)-b-D-glucopyranosyl(146)-b-D-glucopyranoside, 3-O-b-D- xylopyranosyl(146)-b-D-glucopyranosyl(146)-b-D-glucopyranosyl oleanolic acid 28-O-b-D-glucopyranosyl ester and 3-O-b-D- glucopyranosyl(146)-b-D-glucopyranosyl oleanolic acid 28-b-D-glucopyranosyl(146)-b-D-glucopyranosyl ester on the basis of hydrolysis and spectral evidence, including 1D- and 2D-NMR (TOCSY, ROESY, HMQC and HMBC) and FABMS analyses. 72000 Elsevier Science Ltd. All rights reserved.
Gymnema sylvestre, Asclepiadaceae, Oleanane saponins
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【期刊论文】Antisweet Saponins from Gymnema sylvestre
叶文才, Wencai Ye, Xin Liu, Qingwen Zhang, Chun-Tao Che, *
J. Nat. Prod. 2001, 64, 232-235,-0001,():
-1年11月30日
Three new oleanane-type triterpene glycosides (1-3), along with the sodium salt of alternoside II (4), were isolated from an ethanol extract of the leaves of Gymnema sylvestre. The structures of these new saponins were identified as 21, -O-benzoylsitakisogenin 3-O-, -D-glucopyranosyl(1f3)-, -D-glucuronopyranoside (1), the potassium salt of longispinogenin 3-O-‚-D-glucopyranosyl(1f3)-,-D-glucuronopyranoside (2), and the potassium salt of 29-hydroxylongispinogenin 3-O-,-D-glucopyranosyl(1f3)-,-D glucuronopyranoside (3). The aglycon of 3, gymnemagenol (3a), was characterized as 3., 16‚, 28, 29-tetrahydroxyolean-12-ene. Structure elucidation was accomplished by interpretation of NMR (DQF-COSY, HMQC, and HMBC) results, FABMS, and hydrolysis. Saponin 1 and the sodium salt of alternoside II (4) exhibited antisweet activity.
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【期刊论文】Five New Triterpene Saponins from Pulsatilla patens var. multifida
叶文才, Wencai Ye, Guoshi Pan, Qingwen Zhang, Chun-Tao Che, *, Houming Wu
J. Nat. Prod. 1999, 62, 233-237,-0001,():
-1年11月30日
The roots of several Pulsatilla species (Ranunculaceae) are used for "blood-cooling" and detoxifying effects in traditional Chinese medicine.1 A number of Pulsatilla species, such as P. ambigua, P. chinensis, P. dahurica, P. koreana, and P. turczaninovii, are employed in treating diarrhea, vaginal trichromoniasis, and bacterial infections, and pharmacological investigations have suggested that the triterpene saponins are important bioactive components. 2-6 We have previously reported on the isolation and structural elucidation of new triterpene glycosides such as pulsatillosides A and B from P. chinensis 5 and patensin from P. patens var. multifida.6 Further investigation of the latter plant has now led to the purification of additional saponin constituents. In this paper we describe the isolation of seven saponins, the structures of which were determined with the aid of 1D and 2D NMR (13C, 1H, HMQC, HMBC, and ROESY) techniques, FABMS, and hydrolysis. An extensive search of the literature 7-11 indicated thatcompounds 1-5 are new structures.
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