中国科技论文在线

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2005年06月02日

【期刊论文】mlllethoxyphenyl) emthe in Aqueous Media

宋宝安， Song Yang， Bao-AnSong， * HuaZhang， De-Yu Hu， Lin-Hong Jin， and Gang Liu

，-0001，（）：

-1年11月30日

An environmentally benign and effcient process for the preparation of 1-(2, 3, 4-trimethoxyphenyl)-2-sub-stituted heterocyclic thio ethanone derivatives was achieved by the reactiohns of mercapto compounds with 2-bromo-1-(2, 3, 4-trimenthoxyphenyl) ethanone in water mediated by indium in very high yields. Antifungal activities of the compoumds were examined and moderate activity was obtained.

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2005年06月02日

【期刊论文】Synthesis and bioactivity of 2-cyanoacrylates containing a trifluoromethylphenyl moiety

宋宝安， Baoan Song*， Song Yang， Huimin Zhong， Linhong Jin， Deyu Hu， Gang Liu

Journal of Fluorine Chemistry 126 (2005) 87-92，-0001，（）：

-1年11月30日

摘要

A series of 2-cyanoacrylates containing a trifluoromethylphenyl moiety were synthesized in three steps: ethyl 2-cyano-3, 3-dimethylthioacrylate was prepared from ethyl cyanoacetate with carbon disulfide and dimethyl sulfate, then its reaction with 4-trifluoromethylaniline yielded ethyl 2-cyano-3-(4-trifluoromethylphenylamino)-3-methylthioacrylate, and then reacted with an alkylamine. The new structures were verified by elemental analysis, IR, 1H NMR and mass spectra. In the MTT test, these new compounds were found to possess high antitumor activities against PC3 and A431 cells.

Trifluoromethylphenylcyanoacrylate， Synthesis， Antitumor bioactivity

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2005年06月02日

【期刊论文】Synthesis and Bioactivity of a-Aminophosphonates Containing Fluorine

宋宝安， Bao-An Song*， Yang-Lan Wu， Song Yang， De-Yu Hu， Xiang-Qiong He and Lin-Hong Jin

Molecules 2003, 8, 186-192，-0001，（）：

-1年11月30日

摘要

Twenty-one a-aminophosphonates containing fluorine were synthesized by Mannich-type reactions. Their structures were established by elemental analysis, IR, 1H-NMR and MS. In field tests, some of these new compounds display high antiviral activity against the tobacco mosaic virus (TMV). The molecular geometry of compound 4f was determined by X-ray diffraction structure analysis.

a-Aminophosphonates， synthesis， bioactivity