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2005年02月24日

【期刊论文】Enzyme-catalyzed Transesterification of Unusual Substrate: Synthesis of Acyclovir and L-ascorbic Acid (Vitamin C) Vinyl Esters

林贤福, Xing Tao XUE, De Shui L

Chinese Chemical Letters Vol. 14, No.2, pp 163-166, 2003,-0001,():

-1年11月30日

摘要

The synthesis of acyclovir and L-ascorbic acid with divinyladipate was performed with alkaline protease from Bacillus subtilis and lipase from Lipozyme (immobilized from Mucor miehei) in different anhydrous organic solvents. Two corresponding derivatives were obtained.

Alkaline protease,, lipase,, transesterification,, acyclovir,, vitamin C,, vinyl ester.,

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2005年02月24日

【期刊论文】Regioselective Synthesis of Polymerizable Vinyl Guaifenesin Esters Catalyzed by an Alkaline Protease of Bacillus subtilis

林贤福, Na WANG, Qi WU, Jian Ming XU, Xiu Ming JIANG, Xian Fu LIN*

Chinese Chemical Letters Vol. 15, No.2, pp 175-178, 2004,-0001,():

-1年11月30日

摘要

Three polymerizable vinyl guaifenesin esters with different acyl donor carbon chain lengths (C4,C6,C10) were regioselectivly synthesized by an alkaline protease from Bacillus subtilis in pyridine at 50

Vinyl guaifenesin ester,, regioselectivity,, alkaline protease,, transesterification.,

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2005年02月24日

【期刊论文】Regiospecific Addition of Uracil to Acrylates Catalyzed by Alkaline Protease from Bacillus subtilis

林贤福, Ying CAI, Jian Yi WU, Na WANG, Xiao Feng SUN, Xian Fu LIN*

Chinese Chemical Letters Vol. 15, No.5, pp 594-596, 2004,-0001,():

-1年11月30日

摘要

Michael addition reactions of uracil to acrylates were catalyzed by an alkaline protease from Bacillus subtilis in dimethyl sulfoxide at 55℃ for 72 h. The adducts were determined by TLC, IR and 1H NMR.

Alkaline protease,, Michael addition,, uracil,, pyrimidine.,

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2005年02月24日

【期刊论文】Enzyme-Catalyzed Synthesis of Some Vinyl Drug Esters in Organic Medium

林贤福, De-Shui Lv, Xing-Tao Xue, Na Wang, Qi Wu, and Xian-Fu Lin*

PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY Vol. 34, No.1, pp. 97-107, 2004,-0001,():

-1年11月30日

摘要

A series of vinyl drug esters was synthesized using acyclovir and chloramphenicol with different carbon chain length acyl donors by alkaline protease from Bacillus subtilis and Lipozymew respectively, in non-aqueous medium. The corresponding vinyl drug derivatives were confirmed by nuclear magnetic resonance and infrared spectrometry. The influences of different organic solvents, reaction time, temperature, and content of water on synthesis of vinyl chloramphenicol esters were studied.

Vinyl drug esters, Bacillus subtilis, Acyclovir, Chloramphenicol, Lipozyme.,

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2005年02月24日

【期刊论文】A single-enzyme, two-step, one-pot synthesis of N-substituted imidazole derivatives containing a glucose branch via combined acylation/Michael addition reaction†

林贤福, Shi-Ping Yao, ab, De-Shui Lu, a, Qi Wu, Ying Cai, Shan-Hao Xua and Xian-Fu Lin*a

Chem. Commun., 2004, 2006-2007,-0001,():

-1年11月30日

摘要

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  • 林贤福 邀请

    浙江大学,浙江

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