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林贤福, Xing Tao XUE, De Shui L
Chinese Chemical Letters Vol. 14, No.2, pp 163-166, 2003,-0001,():
-1年11月30日
The synthesis of acyclovir and L-ascorbic acid with divinyladipate was performed with alkaline protease from Bacillus subtilis and lipase from Lipozyme (immobilized from Mucor miehei) in different anhydrous organic solvents. Two corresponding derivatives were obtained.
Alkaline protease,, lipase,, transesterification,, acyclovir,, vitamin C,, vinyl ester.,
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林贤福, Na WANG, Qi WU, Jian Ming XU, Xiu Ming JIANG, Xian Fu LIN*
Chinese Chemical Letters Vol. 15, No.2, pp 175-178, 2004,-0001,():
-1年11月30日
Three polymerizable vinyl guaifenesin esters with different acyl donor carbon chain lengths (C4,C6,C10) were regioselectivly synthesized by an alkaline protease from Bacillus subtilis in pyridine at 50
Vinyl guaifenesin ester,, regioselectivity,, alkaline protease,, transesterification.,
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林贤福, Ying CAI, Jian Yi WU, Na WANG, Xiao Feng SUN, Xian Fu LIN*
Chinese Chemical Letters Vol. 15, No.5, pp 594-596, 2004,-0001,():
-1年11月30日
Michael addition reactions of uracil to acrylates were catalyzed by an alkaline protease from Bacillus subtilis in dimethyl sulfoxide at 55℃ for 72 h. The adducts were determined by TLC, IR and 1H NMR.
Alkaline protease,, Michael addition,, uracil,, pyrimidine.,
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【期刊论文】Enzyme-Catalyzed Synthesis of Some Vinyl Drug Esters in Organic Medium
林贤福, De-Shui Lv, Xing-Tao Xue, Na Wang, Qi Wu, and Xian-Fu Lin*
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY Vol. 34, No.1, pp. 97-107, 2004,-0001,():
-1年11月30日
A series of vinyl drug esters was synthesized using acyclovir and chloramphenicol with different carbon chain length acyl donors by alkaline protease from Bacillus subtilis and Lipozymew respectively, in non-aqueous medium. The corresponding vinyl drug derivatives were confirmed by nuclear magnetic resonance and infrared spectrometry. The influences of different organic solvents, reaction time, temperature, and content of water on synthesis of vinyl chloramphenicol esters were studied.
Vinyl drug esters, Bacillus subtilis, Acyclovir, Chloramphenicol, Lipozyme.,
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林贤福, Shi-Ping Yao, ab, De-Shui Lu, a, Qi Wu, Ying Cai, Shan-Hao Xua and Xian-Fu Lin*a
Chem. Commun., 2004, 2006-2007,-0001,():
-1年11月30日
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