To determine if milk-borne insulin-like growth factor I (IGFI) is absorbed in neonatal piglets, recombinant human IGF-I was iodinated and then administered via an oral-gastric tube to newborn and 3-day-old piglets together with fluorescent isothiocyanate dextran (FITC-D70s, a macromolecular marker for assessment of gut closure). Results showed that total radioactivity and trichloroacetic acid (TCA)-precipitable radioactivity rose significantly in the plasma of both newborn and 3-day-old piglets 1 hour after oral-gastric administration of 125I-IGF-I, although the magnitude of increase was greater in newborns than in 3-day-old piglets. In contrast, significant absorption of FITC-D70s was observed only in newborn piglets but not in 3-day-old piglets. Chromatographic analysis revealed that 125I-IGF-I represented up to 20% of total plasma radioactivity in the newborns and up to 10% in the 3-day-old piglets. The 125I-IGF-I found in the plasma was mostly bound to IGF-binding proteins. These results indicate that milkborne IGF-I can be absorbed in neonatal piglets and the absorption is independent of gut closure.

为研究胰岛素和酶（胰蛋白酶和糜蛋白酶）解配方奶粉是否促进初生仔猪的组织生长和功能成熟，本试验比较了饲喂配方奶粉与饲喂配方奶粉补加胰岛素（60mIU/ml）或酶解配方奶粉3d后仔猪小肠的重量和长度，组织形态学结构，粘膜DNA，RNA和蛋白质含量、及小肠内容物中乳糖酶、麦芽糖酶和厉碱性磷酸酶活性。饲喂配方奶粉加胰岛素或酶解配方奶粉的仔猪，与饲喂配方奶粉的仔猪相比，小肠的重量、长度、组织形态学结构及粘膜的DNA和RNA含量均无显著变化（P＞0.05）。但饲喂配方奶粉补加胰岛素的仔猪小肠粘膜尤其是回肠后段粘膜的重量和蛋白质含量显著高于饲喂配方奶粉的仔猪（Ｐ＜0.05或Ｐ＜0.01）。与仅喂配方奶粉的仔猪相比，饲喂配方奶粉补加胰岛素的仔猪小肠内容物中乳糖酶、麦芽糖酶和碱性磷酸酶总活性显著升高；饲喂酶解配方奶粉的仔猪小肠内容物中乳糖酶和碱性磷酸酶总活性显著升高（Ｐ＜0.01）。结果表明，口饲胰岛素刺激小肠粘膜尤其是回肠后段粘膜重量和蛋白质含量的增加及小肠内容物中乳糖酶、麦芽糖酶和碱性磷酸酶总活性的升高；酶解配方奶粉中含有能刺激初生仔猪小肠发育的活性物质。

The pancreas consists of two histologically distinct and functionally independent components, i.e., endocrine islets and exocrine acini. Cells in the endocrine islets produce hormones and regulate body metabolism via the blood circulation, while cells in the exocrine acini secrete digestive enzymes through the duct system into the duodenal lumen. The structure of the pancreas and its postnatal developmental changes in humans and laboratory rodents have been intensively reviewed in more recent publications (1-3). A similar review is lacking for the domestic animal species. This chapter focuses on morphological structure of the pancreas in pigs and its growth and structural changes during the postnatal period. Wherever possible, information derived directly from studies of pigs is used, or otherwise species origin of the data is defined. Comparisons with other domestic animal species are made when information is available.

为研究胰岛素和酶解配方乳是否促进初生仔猪胃肠道的生长发育，本试验比较了饲喂配方乳、配方乳补加胰岛素（60mIU/ml）或酶（胰蛋白酶和糜蛋白酶）解配方乳三天后仔猪胃肠的重量，肠道长度，肠粘膜DNA、RNA和蛋白质含量，血浆中皮质醇、胰岛素和胃泌素的水平。饲喂配方乳补加胰岛素或酶解配方乳的仔猪，与饲喂配方乳的仔猪相比，胃、小肠、结肠的重量，小肠和结肠的长度，小肠粘膜DNA、RNA含量和结肠粘膜DNA、RNA、蛋白质含量均无显著变化（P>0.05）；血浆中皮质醇、胰岛素水平也无显著差异（P>0.05）。但饲喂配方乳补加胰岛素的仔猪小肠粘膜尤其是回肠后段粘膜的重量（P<0.05）和蛋白质含量（P<0.01）显著高于饲喂配方乳的仔猪；饲喂酶解配方乳仔猪血浆的胃泌素水平均显著（P<0.01）高于饲喂配方乳的仔猪，酶解配方乳中可能含有刺激初生仔猪胃泌素释放的物质。