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高坤, 王文蜀, 贾忠建*
化学学报,2003,61(7):1065-1070,-0001,():
-1年11月30日
从假橐吾全草中分离得到四对新的(1/2,3/4,5/6,7/8)和一对已知的(9/10)8,9-开环艾里莫芬内酯型倍半萜。每一对均为C-8位差向异构体。它们的结构通过波谱方法阐明并通过酰化或酯化分离后得到证实。活性筛选实验表明,1/2和3/4具有细胞毒活性。
假橐吾,, 开链艾里莫芬内酯型倍半萜,, 差向异构体,, 细胞毒活性
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【期刊论文】Eudesmane derivatives and other constituents from Saussurea parviflora
高坤, Zhong-Duo Yang, Kun Gao, Zhong-Jian Jia*
Phytochemistry 62(2003)1195-1199,-0001,():
-1年11月30日
A survey of the whole plant of Saussurea parviflora afforded three compounds 11,12,13-trihydroxy-4 (15), 8-eudesmadiene-9-one, eudesman-813,12-olide-l-O-13-D-glucoside and 113,313-dihydroxyursa-9(11), 12-diene-3-octadecanoate, as well as 13 known compounds. Their structures were elucidated on the basis of spectral evidence, especially by using NMR spectroscopic techniques. In addition, encelin exhibited effective antitumor activity on L02, SMMC-7721 and HO-8910 cells.
Saussurea parviflora, Compositae, Eudesmane derivatives, Antitumor activity
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【期刊论文】Eremophilenolides and Other Constituents from the Roots of Liaularia saaitta
高坤
,-0001,():
-1年11月30日
Chemical investigation of the roots of Ligularia sagitta has resulted in the characterization of six eremophilenolides 6β,8βdimethoxy-1Oβ-hydroxyeremophil-7(11)-en-12,8a-olide (1), 6βan-geloyloxy-1Oβ-hydroxy-8β-methoxyeremophil-7(11)-en-12,8a-olide (2), 6/3-(2'-methylbutanoyloxy)-10β-hydroxy-8β-methoxy-eremophil-7(11)-en-12,8a-olide (3), 6β-angeloyloxy-1Oβ-hydro-xy-8a-methoxyeremophil-7(11)-en-12,8β-olide (4), 6β-(2'me-thylbutanoyloxy)-10β-hydroxy-8a-methoxyeremophil-7(11)-en-12.8β-olide (5) and 8β. lOβ-dihvdroxv-6β-methoxveremoohil-7(ll)-en-12,8a-olide (6), together with one monoterpene (3R,4R,65)-3,6-dihydroxy-l-menthene (7), two triterpenes lupeoi (8) and ursolic acid (9), and β-sitosterol (10). The structures of five new constituents (1-5) were elucidated by spectroscopic methods including 2D-NMR experiments. The compounds 1, 5 and 7 showed antibacterial activity by being assayed against Staphylococcus aureus, Bacillus subtilis and Escherichia coll.
Ligularia sagitta
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【期刊论文】Two new compounds from Ligularia dolichobotrys
高坤, ER-WEI LI, KUN GAO, ZHONG-JIAN JIA
,-0001,():
-1年11月30日
Two new compounds, a stigmasterol (1) and an eremophilenolide (2), were isolated from Ligularia dolichobotrys (Diels) together with ten known sesquiterpenoids, two known triterpenes and five known sterols. Their structures were elucidated by spectroscopic methods (IR, MS, 1H, 13C and 2D NMR). In addition, bakkenolide A (3) exhibited effective antitumor activity to human leukemia cells (HL-60), human hepatorna cells (Bel-7402) and human ovarian neoplasm cells (HO-8910).
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【期刊论文】New Sesquiterpenes from Ligulariopsis shichuana
高坤, Wen-Shu Wang, Kun Gao* and Zhong-Jian Jia*
Journut of the Chinese Chemical Society, 2004, 51, 417-422,-0001,():
-1年11月30日
A thorough investigation of Ligulariopsis shichuana afforded five new sesquiterpenes, including 1β, 10β-epoxy-3a-angeloyloxy-9β-acetoxy-8a, 11β-dihydroxybakkenolide (1), 1β, 7-dihydroxy-3β-acetoxy-noreremophil-6(7),9(10)-dien-8-one (2), 8a-hydroxy-3-oxoeremophil-1 (2),7(11), 9(10)-trien-813(12)-elide (3), 1β, 10β-dihydroxy-3β-acetoxyeremophil-7(11), 8 (9)-dien-8(12)-elide (4) and 1β, 10β-epoxy-8,12-dihy-droxy-3β-acetoxy-9β-angeloyloxyeremophil-7(11)-en-8, 12-disemiketal (5). Their structures were estab-lished by spectroscopic methods and 2D NMR techniques. In addition, bakkenolide (1) and eremophileno-lides (5) showed antibacterial and cytotoxic activities.
Ligulariopsis shichuana, Compositae, Sesquiterpenes, Antibacterial activity, Cytotoxic activity.,
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