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高坤, 王文蜀, 贾忠建*
化学学报,2003,61(7):1065-1070,-0001,():
-1年11月30日
从假橐吾全草中分离得到四对新的(1/2,3/4,5/6,7/8)和一对已知的(9/10)8,9-开环艾里莫芬内酯型倍半萜。每一对均为C-8位差向异构体。它们的结构通过波谱方法阐明并通过酰化或酯化分离后得到证实。活性筛选实验表明,1/2和3/4具有细胞毒活性。
假橐吾,, 开链艾里莫芬内酯型倍半萜,, 差向异构体,, 细胞毒活性
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【期刊论文】New Sesquiterpenes from Ligulariopsis shichuana
高坤, Wen-Shu Wang, Kun Gao* and Zhong-Jian Jia*
Journut of the Chinese Chemical Society, 2004, 51, 417-422,-0001,():
-1年11月30日
A thorough investigation of Ligulariopsis shichuana afforded five new sesquiterpenes, including 1β, 10β-epoxy-3a-angeloyloxy-9β-acetoxy-8a, 11β-dihydroxybakkenolide (1), 1β, 7-dihydroxy-3β-acetoxy-noreremophil-6(7),9(10)-dien-8-one (2), 8a-hydroxy-3-oxoeremophil-1 (2),7(11), 9(10)-trien-813(12)-elide (3), 1β, 10β-dihydroxy-3β-acetoxyeremophil-7(11), 8 (9)-dien-8(12)-elide (4) and 1β, 10β-epoxy-8,12-dihy-droxy-3β-acetoxy-9β-angeloyloxyeremophil-7(11)-en-8, 12-disemiketal (5). Their structures were estab-lished by spectroscopic methods and 2D NMR techniques. In addition, bakkenolide (1) and eremophileno-lides (5) showed antibacterial and cytotoxic activities.
Ligulariopsis shichuana, Compositae, Sesquiterpenes, Antibacterial activity, Cytotoxic activity.,
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【期刊论文】Two New Diterpene Acetylxylosides from Aster veitchianus
高坤, Er Wei LI, Kun GAO*, Zhong Jian JIA*
Chinese Chemical Letters Vol. 15, No. 4, pp 425-427, 2004,-0001,():
-1年11月30日
Two new acetylxylosides, ent-manool-13-O-β-D-2'-acetylxylopyranoside (1) and entmanool 13-O-β-D-2', 4'-diacetylxylopyranoside (2) were isolated from Aster veitchianus. Their structures were elucidated by spectroscopic methods.
Aster veitchianus,, Compositae,, diterpene,, xylosides.,
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【期刊论文】A New Stigmasterol and a New Eremophilenolide from Ligularia dolichobotrys
高坤, Er Wei LI, Kun GAO*, Zhong Jian JIA*
Chinese Chemical Letters Vol.15, No.2, pp 194-196, 2004,-0001,():
-1年11月30日
A new stigmasterol 3β, 7α, 22-trihydoxystigmast-5-ene (1) and a new eremophilenolide 8α-methoxy-6β-angeloyloxyeremophil-7(11)-en-8β, 12-olide-14-oic acid (2) were isolated from Ligularia dolichobotrys Diels. Their structures were deduced on the basis of spectral data.
Ligularia dolichobotrys Diels,, Compositae,, stigmasterol,, eremophilanolide.,
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【期刊论文】Eremophilenolides and Other Constituents from the Roots of Liaularia saaitta
高坤
,-0001,():
-1年11月30日
Chemical investigation of the roots of Ligularia sagitta has resulted in the characterization of six eremophilenolides 6β,8βdimethoxy-1Oβ-hydroxyeremophil-7(11)-en-12,8a-olide (1), 6βan-geloyloxy-1Oβ-hydroxy-8β-methoxyeremophil-7(11)-en-12,8a-olide (2), 6/3-(2'-methylbutanoyloxy)-10β-hydroxy-8β-methoxy-eremophil-7(11)-en-12,8a-olide (3), 6β-angeloyloxy-1Oβ-hydro-xy-8a-methoxyeremophil-7(11)-en-12,8β-olide (4), 6β-(2'me-thylbutanoyloxy)-10β-hydroxy-8a-methoxyeremophil-7(11)-en-12.8β-olide (5) and 8β. lOβ-dihvdroxv-6β-methoxveremoohil-7(ll)-en-12,8a-olide (6), together with one monoterpene (3R,4R,65)-3,6-dihydroxy-l-menthene (7), two triterpenes lupeoi (8) and ursolic acid (9), and β-sitosterol (10). The structures of five new constituents (1-5) were elucidated by spectroscopic methods including 2D-NMR experiments. The compounds 1, 5 and 7 showed antibacterial activity by being assayed against Staphylococcus aureus, Bacillus subtilis and Escherichia coll.
Ligularia sagitta
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