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【期刊论文】Eudesmane derivatives and other constituents from Saussurea parviflora
高坤, Zhong-Duo Yang, Kun Gao, Zhong-Jian Jia*
Phytochemistry 62(2003)1195-1199,-0001,():
-1年11月30日
A survey of the whole plant of Saussurea parviflora afforded three compounds 11,12,13-trihydroxy-4 (15), 8-eudesmadiene-9-one, eudesman-813,12-olide-l-O-13-D-glucoside and 113,313-dihydroxyursa-9(11), 12-diene-3-octadecanoate, as well as 13 known compounds. Their structures were elucidated on the basis of spectral evidence, especially by using NMR spectroscopic techniques. In addition, encelin exhibited effective antitumor activity on L02, SMMC-7721 and HO-8910 cells.
Saussurea parviflora, Compositae, Eudesmane derivatives, Antitumor activity
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【期刊论文】Comparative Study of Activities between Verbascoside and Rutin by Docking Method
高坤, Kun Gaoa, b, B o Tao Fan*a, Nadia El Fassia, Krystyna Zakrzewskac, Zhongjian Jiab, Rongliang Zhengd, Annick Panayea, T. Couesnona, and Jean-Pierre Douceta
,-0001,():
-1年11月30日
Verbascoside and rutin possess anti-cancer properties and are capable of repairing DNA damaged by oxygen radicals, acting as powerful antioxidants. Based on kinetic measurements and experiments on tumor cells, docking studies of the two ligand molecules with the receptor telomeric DNA fragments have been carried out. The docking calculations performed using JUMNA software showed that the both molecules can be docked into the minor groove of telomeric DNA and form complexes with suitable geometry for electron transfer between guanine radicaland ligands. The reaction mechanism via the electron transfer process is further confirmed through energy calculations for transition states using MOPAC 93 program. Complexes can be formed without major distortion of DNA structure and are further stabilized by the interaction of DNA with the saccharide side-groups. By comparing their energies, the difference of activities of the two compounds can be explained.
Verbascoside, Rutin, Biological activity, Telomeric Fragment, Docking study
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【期刊论文】A New Stigmasterol and a New Eremophilenolide from Ligularia dolichobotrys
高坤, Er Wei LI, Kun GAO*, Zhong Jian JIA*
Chinese Chemical Letters Vol.15, No.2, pp 194-196, 2004,-0001,():
-1年11月30日
A new stigmasterol 3β, 7α, 22-trihydoxystigmast-5-ene (1) and a new eremophilenolide 8α-methoxy-6β-angeloyloxyeremophil-7(11)-en-8β, 12-olide-14-oic acid (2) were isolated from Ligularia dolichobotrys Diels. Their structures were deduced on the basis of spectral data.
Ligularia dolichobotrys Diels,, Compositae,, stigmasterol,, eremophilanolide.,
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【期刊论文】New Sesquiterpenes from Ligulariopsis shichuana
高坤, Wen-Shu Wang, Kun Gao* and Zhong-Jian Jia*
Journut of the Chinese Chemical Society, 2004, 51, 417-422,-0001,():
-1年11月30日
A thorough investigation of Ligulariopsis shichuana afforded five new sesquiterpenes, including 1β, 10β-epoxy-3a-angeloyloxy-9β-acetoxy-8a, 11β-dihydroxybakkenolide (1), 1β, 7-dihydroxy-3β-acetoxy-noreremophil-6(7),9(10)-dien-8-one (2), 8a-hydroxy-3-oxoeremophil-1 (2),7(11), 9(10)-trien-813(12)-elide (3), 1β, 10β-dihydroxy-3β-acetoxyeremophil-7(11), 8 (9)-dien-8(12)-elide (4) and 1β, 10β-epoxy-8,12-dihy-droxy-3β-acetoxy-9β-angeloyloxyeremophil-7(11)-en-8, 12-disemiketal (5). Their structures were estab-lished by spectroscopic methods and 2D NMR techniques. In addition, bakkenolide (1) and eremophileno-lides (5) showed antibacterial and cytotoxic activities.
Ligulariopsis shichuana, Compositae, Sesquiterpenes, Antibacterial activity, Cytotoxic activity.,
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【期刊论文】Two new compounds from Ligularia dolichobotrys
高坤, ER-WEI LI, KUN GAO, ZHONG-JIAN JIA
,-0001,():
-1年11月30日
Two new compounds, a stigmasterol (1) and an eremophilenolide (2), were isolated from Ligularia dolichobotrys (Diels) together with ten known sesquiterpenoids, two known triterpenes and five known sterols. Their structures were elucidated by spectroscopic methods (IR, MS, 1H, 13C and 2D NMR). In addition, bakkenolide A (3) exhibited effective antitumor activity to human leukemia cells (HL-60), human hepatorna cells (Bel-7402) and human ovarian neoplasm cells (HO-8910).
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