本实验是在N 2低温等离子体技术(LGDP)对Dacron材料表面改性的基础上进行的。用非反应性气体Ar作载气，在其表面引入一些亲水基团，接枝抗细菌粘附的聚乙二醇和肝素。对改性后的材料作体外表皮葡萄球菌(Staphylococcus Ep idermidis, SE)的动态粘附实验，其抗细菌粘附的能力有较为明显的提高，与未改性材料相比，细菌粘附减少80%以上。

本文在血磷与生物材料钙化关系的研究基础上，从生物瓣材料植入体内后的组织学变化，探讨了AKP与生物瓣钙化的关系。组织学和超微结构研究表明：生物瓣组织在植入体内后有进行性形态学变化：包括形成包囊，刺激组织增生和细胞浸润，包囊诱使细胞变性，细胞在变性中使AKP活力升高,变性和坏死细胞的降解成分便成为钙结晶的成核部位；AKP使局部PO3 -4积累，促进钙化发生。由此本文探讨了生物瓣钙化中AKP的发生机理和AKP与钙化的关系。

为了进一步探讨AKP与钙化的关系，本文采用佝偻病大鼠的骺骨生长板为材料进行体外钙化实验，从AKP活力的变化追踪钙化速度的变化；从钙化速度的变化考查AKP活力的变化；比较生理性钙化和病理性钙化中AKP 的作用，从而为生物瓣钙化的机理提出了新的依据。

介绍了对人工心瓣植入用涤纶布(Dacron)表面以紫外辐照为主进行接枝改性的方法，在其材料表面引入聚乙二醇(Po lyeth lene glyco l, PEG)，利用PEG的“化学放大”作用再引入肝素(Heparin, Hep)，改性后的材料抗细菌粘附效果显著，与未改性材料相比，细菌粘附减少90%。

Porous calcium polyphosphate(CPP) have been shown to promise for tissue engineered implant application. The process from Ca(H2PO4)2 to CPP, as a polycondensation reaction, has been researched to evaluate the number average degree of polymerization. CPP with different degree of polymerization were prepared by controlling the calcining time. Amorphous and different crystalline CPP were prepared by the quenching from the melt and crystallization of amorphous CPP. Two specimens were soaked into citric acid and tris-buffer solution for. to 30 days. The weight loss of CPP with different degree of polymerizations and crystal types are different. With the increasing of degree of polymerization, the weight loss during the degradation is decreasing, contrarily the strength of CPP is increasing. The degradation velocity of amorphous CPP, α-CPP,β-CPP and γ-CPP with the same degree of polymerization decreased in turn at the same period. The full weight loss period of CPP can be changed between 17 days and more than. year. The degradation and deposition was faster in the citric acid than the tris-buffer solution.