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【期刊论文】Tracing process of β2TCP ceramics in vivo with 45Ca ①
李世普, LI Shi-pu, DAI Hong-lian, YAN Yu-hua, WANG Xin-yu, XIONG Xian-li, ZHENG Qi-xin, DU Jing-yuan
Trans. Nonferrrous Met. Soc. China, 2004, 14 (1): 20-24,-0001,():
-1年11月30日
The metabolic way of calcium ions which was released due to in vivo degradation of porous β2TCP ceramics was studied by using the radioisotope 45Ca as tracer. The result shows that some of the calcium ions enter blood and take part in the circulation. These calcium ions distribute into organs and tissues (such as liver, kidney, brain, heart, lung, spleen and stomach) and participate in the metabolisms of body. There is neither the accumulation of calcium ions, nor the lesion or pathologic calcification of the organs and tissues. Some of the calcium ions that enter the near-end femur, ulna and skull are reused by bony tissue to take part in both local mineralization processes during bone healing, or are stored in calcium pool which can participate in the whole body circulating. In the cyclical process, other calcium ions are excreted with urine and feces through kidney and liver. It is indicated that the degradation products of β2TCP ceramics can take part in the physiological metabolic process of normal bone and tissue.
β-TCP ceramics, 45Ca tracing, metabolism, mineralization
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【期刊论文】The Effect of CaCo3 and TiO2 Nanometer Particles on A549 and L929 Cells
李世普, Lingyun Feng, Shipu Li, Yuhua Yan and Cuishou Liu
Key Eegineering Materials Vols, 192-195 (2001) pp. 325-325,-0001,():
-1年11月30日
Biornedical nanometer materials are a new field of biomaterials. In this work, CaCo2 and TiO2 nanomete partcles were prepared by sol-gel and chemical homogencous precipitation reaction with ultrasonic wave irradiation. Cell proliferation was measured by MTT method. It is shown that in vitro CaCo3 particles in hibited significantly on growh and proliferation of lung cancer cells A549, but improved slightly the growth of L929 Cells. On the other hand, TiO2 Particles had the same effect of inhibition on A549 cells, however, it obviously restrained the growht of L929 SEM observation demonstrated that L929 cells fadd somehow after treatment of TiO2 particles, but the morphology of L929 cells was not changed after treatment of CaCO3 particles, A549 cells became the typical apoptosis body after treated by TiO2 and CaCO3 particels.
Biological Effect,, Cell Culture,, Morphoiogy,, Nano-Meter Particles
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【期刊论文】Study on the Surface Modiflcation of Modical Sillcon Rubber by Biomimetic Synthesizing HA
李世普, Xinyu Wang, Shipu Li, Yuhua Yan, and Jing Yang
Key Engineering Materials Vols, 192-195 (2001) pp. 295-298,-0001,():
-1年11月30日
Biomimetic Synthesis,, HA,, Mecharisrn,, Sillicon Rubber
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【期刊论文】Preparing Plate-Like HAP by the Pulse Addition
李世普, Xiaoming Chen, Shipu Li and Fei Liang
Key Engineering Materials Vols, 192-19 5(2001) pp. 239-242,-0001,():
-1年11月30日
In the paper, the traditional preparing method of hydroxyapatite (HAP) was improved on the basis of full research for structure, charge character and adsorption character of HAP surface, Utilizing the intermittent addition method of reaction solution rather than a slow continuous oropping addition method, and controlling the pH value (7.0-7.5) and the adding order of reactants and so on, a final product the near plate and granular-like HAP can be got, The character and structure of the product were analyzed through XRD, IR and SEM, and the mechanism that CI-1 ion influences the crystallizing of HAP was discussed.
Crystallization,, Plate-Like Hydroxyapatite,, Preparation
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【期刊论文】Preparation for femur prosthesis of ceramic-metal combination artificial hip joint ①
李世普, WANG Xin-yu, LI Shi-pu, CHENG Xiao-ming, HE Jian-hua
Trans. Nonferrrous Met. Soc. China, Dec. 2002, 12 (6): 1135-1137,-0001,():
-1年11月30日
Al2O3 material was synthesized by using high purity alumina micro-powder and Mg-Zr-Y composite additives at temperature of 1600℃, which had good mechanics property of 416MPa bending strength and 5.46MPa·m1/2 fracture tough-ness. Femur head prosthesis of hip joint was prepared by using this material; Ti alloy femur handle was sprayed bioactive hy-droxyapatite (HA) by plasma on surface, which improves the chemistry stability and biocompatibility of Ti alloy; eramic-metal combination artificial hip joint femur prosthesis was made by combining Al2O3 femur head with Ti alloy femur handle, so the manufacturing process is improved and the property and application flexibility are advanced.
Al2O3, mechanics property, femur prosthesis, spraying, combination
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