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黄培强
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-1年11月30日
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黄培强 , Bi-Yan He, Tian-Jun Wu, Xian-Yong Yu and Pei-Qiang Huang*
Tetrahedron: Asymmentry 14(2003)2101-2108,-0001,():
-1年11月30日
A flexible non-amino acid-based formal asymmetric synthesis of naturally occurring antimicrobial (2R,3S)-2-aminotetradeca-5,7-dien-3-ol is reported. The method features a flexible and highly regioselective Grignard addition to (S)-malimide followed by a trans-diastereoselective reductive deoxygenation. The scope and limitations of the highly regio and diastereoselective reductive alkylation of malimides were defined. A remarkable protecting group effect on the regio and diastereoselective reductive alkylation of malimides was observed.
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【期刊论文】DIBAL-H-H2NR and DIBAL-H-HNR1R2
黄培强 , Pei-Qiang Huang, * Xiao Zheng and Xian-Ming Deng
Tetrahedron Letters 42(2001)9039-9041,-0001,():
-1年11月30日
The reaction of a lactone or an ester with organoaluminum species generated from DIBAL-H-H2NR or DIBAL-H-HNR1R2
aminolysis, DIBAL-H, Weinreb amides, amides.,
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黄培强 , Liang-Xian Liu, Yuan-Ping Ruan, Zheng-Qing Guo, and Pei-Qiang Huang*
J. Org. Chem. 2004, 69, 6001-6009,-0001,():
-1年11月30日
A general approach to (5S,6R)-6-alkyl-5-benzyloxy-2-piperidinones based on the regioand diastereoselective reductive alkylation of (S)-3-benzyloxyglutarimide 7 is described. This method opens an entrance to chiral nonracemic substituted 3-piperidinols. The versatility of the method is illustrated by the asymmetric syntheses of neurokinin substance P receptor antagonist L-733,061 (ent-1), (-)-deoxocassine (4), and an inhibitor of HIV proteases (5a).
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黄培强 , Pei-Qiang Huang, * Liang-Xian Liu, Bang-Guo Wei, and Yuan-Ping Ruan
Org. Lett., Vol. 5, No. 11, 2003,-0001,():
-1年11月30日
Selective and potent neurokinin substance P receptor antagonists (+)-L-733, 060 (1) and (+)-CP-99, 994 (2) have been synthesized starting from a new (3S)-piperidinol synthon derived from L-glutamic acid. The methods featured a C-2 regioselective reduction of glutarimide (9), Lewis acid-promoted Si to C-2 phenyl group migration of 10, and stereoselective reduction of acetylated oxime 19 as the key steps.
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