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【期刊论文】In vitro release of protein from poly (butylcyanoacrylate) nanocapsules with an aqueous core
刘孝波, Sai Li, Yi He, Cao Li, Xiaobo Liu
Colloid Polym Sci (2005) 283: 480-485,-0001,():
-1年11月30日
Factors influencing the in vitro release of bovine serum albumin (BSA) from poly(butylcyanoacrylate) (PBCA) nanocapsules, such as the pH value, BSA loading, the polymeric nanocapsule walls and protein molecular weight, were investigated in detail. The BSA release rate was affected by the degradation rate of the polymeric wall and protein loading. For low molecular weight proteins, the initial burst release was faster than that of high molecular weigh proteins and got to equilibrium quickly. Sodium dodecyl sulfate–polyacrylamide gel electrophoresis results showed that BSA encapsulated within PBCA nanocapsules did not suffer covalent aggregation or fragmentation during the initial days of in vitro incubation. For nanocapsules prepared by interfacial polymerization in waterinoil microemulsions, these findings were useful as a foundation for the development of nanocapsules with desired properties.
Nanocapsules, Protein, release, Poly (, butylcyanoacrylate), , Degradation
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刘孝波, Zhiyong Qian, Sai Li, Yi He, Hailian Zhang, Xiaobo Liu
Z. Qian et al. Biomaterials 25 (2004) 1975-1981,-0001,():
-1年11月30日
In this paper, a new kind of aliphatic biodegradable polyesteramide copolymers P (CL/AU) x/y based on e-caprolactone and 11-aminoundecanoic acid were synthesized by the melt polycondensation method. Hydrolytic degradation behavior of P (CL/AU) copolymers were studied by using FTIR, 1H-NMR and DSC. Chemical compositions, macromolecular weight, thickness of the test sample, and pH of the degradation medium have great effect on degradation rate. The degradation rate decreased with increase in aminoundecanoic acid content, macromolecular weight, and thickness of the test samples, but increased with incubation temperature and pH of the degradation medium. The degradation mechanism was studied according to the mathematical model developed by professor G. opferich.
Polyesteramide, e-caprolactone, Hydrolytic degradation, Degradation mechanism
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【期刊论文】Characterization of Sn-doped BST thin films on LaNiO3–coated Si substrate
刘孝波, Wencheng Hu, Chuanren Yang, Xiaobo Liu, Wei He, Xianzhong Tang
J. Mater Sci: Mater Electron,-0001,():
-1年11月30日
Sn-doped (Ba, Sr) TiO3 (BSTS) thin films have been deposited on highly (200) oriented LaNiO3 (LNO) thin films by sol-gel method. The atomic force microscope (AFM) images exhibited that the dopant Sn did not decrease the crystalline grain size of BST thin films. The structure of the BST film, determined by X-ray diffraction (XRD), presented the higher intensity (110) and (200) peaks, while the latter was distinctly induced by LNO layer. Evidently, Sn-doped BST thin films on LNO/Si substrate were found to decrease the dielectric constant and the dielectric loss, which is favourable to potentially improve the figures of merits (FD) of pyroelectric materials. The BSTS thin films on LNO layer also displayed an excellent leakage current property comparing with the BST thin film on Pt/Ti/SiO2/Si and LNO/Si substrates.
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【期刊论文】Alkaline degradation behavior of polyesteramide fibers: surface erosion
刘孝波, Yi He, Zhiyong Qian, Hailian Zhang, Xiaobo Liu
Colloid Polym Sci (2004) 282: 972-978,-0001,():
-1年11月30日
In this work, a new kind of aliphatic polyesteramide (PEA) copolymer based on €-caprolactone and 6-aminocaproic acid was synthesized by the melt polycondensation method. Biodegradable PEA fibers were processed by the meltspinning method. 1H-NMR, FTIR, SEM, and tensile testing were used to characterize the degradation of PEA fibers in concentrated alkaline solution. The PEA fiber undergoes surface erosion in such concentrated alkaline solutions.
Polyesteramide, Degradation, Fiber, Surface, Erosion
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