运用CB-HRP神经示踪法对内关、公孙配伍机理从神经解剖学角度进行探讨。结果：内关、公孙配伍运用，其针刺信息可在脊髓内经中间内、外侧核的神经元纤维感传至相应脊髓节段，再分别通过与交感神经、副交感神经形成突触联系，形成在脊髓层次的协同增效关系；同时通过两穴在脊髓内相应神经元向孤束核的投射纤维产生突触联系，实现对胃等内脏传入信息在脊髓扣孤柬核水平的调节整合作用。

方法：选用Wister健康成年大鼠，针刺“内关”、“太冲”等穴，用高效液相色谱法(HPLC)观测其对大鼠灌服川芎嗪(TMP)后，川芎嗪在动物体内的靶向吸收现象，以期为针药并举这一有效的治疗方法提供客观的实验依据。结果：相同时间内川芎嗪在针刺相应穴位组大鼠相应器官内含量明显多于单纯灌药组(P<0.05)，

目的：观察针刺对中药有效成分在人体内吸收的影响，探讨针药结合的作用机理。方法：用Freund's完全佐剂给大鼠右后足跖皮内注射，制作关节炎大鼠模型。造模成功后，用药物法、针刺法及针药结合法分别连续治疗l周。在造模前、造模成功后及治疗后分别测定各组大鼠痛阈值；用HPLC法测定治疗后各纽大鼠独活香豆素的血药浓度及在肝脏、肾脏和膀耽等组织器官中的含量。结果：治疗后针药组痛阈值明显高于针刺组及药物组；在相同的时间内针药组大鼠肝脏、肾脏、膀胱中独活香豆素的含量明显高于药物组。结论：针刺特定穴位或穴位群对于大鼠体内特定药物的吸收有趋向性影响。

To observe theeect of acupuncture on the brain-taxis of tetramethylpyrazine (TMP) and toexplore into the LX)derlying mechanisms of combined action of acupuncture and medicine in the trealment of acute cere-bral ischemia. Methods: 37 male Wistar rats were randomly divided into normal control group (n=10), sham-operationgroup (n=10). acute cerebral ischemia (ACI)+ drug group (model grcup, n=8)and ACI+ ctvg puncture gr.upacupuncture group, (n=9). Rat ACI model was established by using photcchemical tnethcd. "Neiguan" (PC6) and"Shuigou"(GV 26) were) punctured and stirrulated wilh both hand manipulalion and electroacupuncture, 30 min and 16hrs after ACI. TMP was given to the rats of the later 2 groups using gastric perlusion method. High pressure chro-matcgraphy (HPLC) was used to datect tha target absorption level of TMP inthe brain. Results: The content of TMP inthe brain in aajpuncture group was significantly highar than that in model group (P<0.01). suggesting that acuVnc-ture can strengthen the brain-taxis of TMP in ACI rats, and combined administratIon of acupuncture and Chinese drugmaybe work better for treatment of acute cefebral infarction. ConclusLon Acupuncture can strengthen the chemo-taxisof TMP to the brain in ACI rats.

以脏补脏疗法是中医脏器疗法的核心内容，它是根据同气相求的原理，利用动物的内脏来补养和治疗人体同名内脏的“虚”与“损”的一种方法，是归经理论的雏形。该文从对中药归经理论的认识、脏器疗法的应用和以脏补脏疗法与中药归经的关系三个方面探讨了以脏补脏疗法的理论基础以及同现代医学靶向给药原理的关系。中药归经、以脏补脏、靶向给药三种理论三种方法殊途同归，其目的是相同的，都是要实现选择性针对治疗的最终理念。