中国科技论文在线

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2010年07月16日

【期刊论文】Synthesis and application of new chiral catalysts for asymmetricalkynylation reactions

鲁桂， Gui Lu， Yue-Ming Li， Xing-Shu Li， Albert S.C. Chan∗

Coordination Chemistry Reviews 249(2005)1736-1744，-0001，（）：

-1年11月30日

Various combinations of chiral ligands and transition metal sources have been used as catalysts in the enantioselective alkynylation of aldehydes and ketones. The results of previous studies and current investigations are reviewed. The factors governing the yields and enantioselectivities are discussed.

Asymmetric catalysis， Enantioselectivity， Alkynylation， Nucleophilic addition

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2010年07月16日

【期刊论文】Enantioselective alkynylation of aromatic aldehydes catalyzed bynew chiral amino alcohol-based ligands

鲁桂， Gui Lu， Xingshu Li， Zhongyuan Zhou， Wing Lai Chan* and Albert S. C. Chan*

Tetrahedron: Asymmetry 12(2001)2147-2152，-0001，（）：

-1年11月30日

摘要

A series of binaphthyl-derived amino alcohols were synthesized and used as catalytic ligands in the asymmetricalkynylation of aromatic aldehydes in the presence of a dialkylzinc reagent. The alkynylation of a variety of aromatic aldehydesgave the corresponding chiral propargylic alcohols in 61–93% e.e.

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2010年07月16日

【期刊论文】Effective activation of chiral BINOL/Ti(OiPr)4 catalyst withphenolic additives for the enantioselective alkynylation ofaldehydes

鲁桂， Gui Lu， Xingshu Li， Gang Chen， Wing Lai Chan* and Albert S. C. Chan*

Tetrahedron: Asymmetry 14(2003)449-452，-0001，（）：

-1年11月30日

摘要

The activation of chiral titanium(IV) complexes with achiral activators, e.g. phenol, is found to provide higher levels of enantioselectivity than those attained with an enantiopure catalyst in the alkynylations of both aromatic and aliphatic aldehydes.

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2010年07月16日

【期刊论文】Titanium-catalyzed enantioselective alkynylation of aldehydes

鲁桂， Gui Lu， Xingshu Li， Wing Lai Chan* and Albert S. C. Chan*

CHEM. COMMUN., 2002, 172-173，-0001，（）：

-1年11月30日

摘要

A simple and practical method to make chiral propargylicalcohols has been developed: in the presence of a titaniumalkoxide catalyst prepared in situ from titanium tetraisopropoxideand (R)-H8-binaphthol, a variety of aromaticaldehydes were converted to the corresponding chiralpropargylic alcohols with very good enantioselectivities (upto 96.2% e.e.) and yields.

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2010年07月16日

【期刊论文】Highly Enantioselective Alkynylzinc Addition to Aromatic AldehydesCatalyzed by Self-Assembled Titanium Catalysts

鲁桂， Xingshu Li， Gui Lu， Wai Him Kwok， and Albert S. C. Chan*

，-0001，（）：

-1年11月30日

摘要

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