肾阴肾阳失衡是性早熟和衰老的病理基础，衰老是“生理性肾虚”，其阴阳失衡是以肾阳虚为主；性早熟的本质是阴虚火旺，其阴阳失调是以肾阴虚为主。由肾气盛衰主导的生长、发育、衰老过程中，主要涉及生长激素轴和性腺轴，性早熟惠儿可见这两轴的提前启动，表现为阴虚火旺；而衰老时是这两轴的率先衰退，表现为阳气虚损。分别采用温补肾阳方药以延缓衰老与滋阴泻火方药以抑制性早熟取得临床与实验的显著效果，通过以药测证，推测发病部位，证明性早熟或衰老，其病理损害是在下丘脑或更高中枢。

目的研究和探讨环境内分泌干扰物（EEDs）与儿童性早熟发病的关系。方法收集2004年5月-2005年9月在我院性早熟专科门诊就诊的初诊患儿79例及正常儿童42例。运用反相高效液相色谱分析法测定性早熟患儿及正常儿童血清中4-壬基酚（4-NP）、二氯二苯二氯乙烯（p，p'-DDE）、邻苯二甲酸-2-乙基己酯（DEHP）的含量。同时测定患儿子宫和卵巢体积、骨密度及血清雌二醇(E2)含量。将血清EEDs含量与靶器官的病变指标做相关性分析及多元线性回归分析。结果每一例正常儿童血清中均检测到一定含量的p，p'-DDE(14.93～40.39ng/ml)，部分正常儿童血清中检测到一定含量的4-NP及DEHP(ND～6.77ng/ml，ND～17.61ng/ml)。性早熟患儿血清中4-NP、p，p'-DDE及DEHP含量显著高于正常儿童（P<0.01）。性早熟患儿血清中4-NP与子宫体积、卵巢体积、骨密度均呈显著正相关(r=0.394，0.286，0.237;P<0.01)；p，p′-DDE与子宫体积呈显著正相关(r=0.306;P<0.01)。4-NP对子宫体积的影响强度p，p'-DDE的1.3倍。结论当前正常儿童也较普遍地收到环境内分泌干扰物的污染，只不过所受污染的程度比性早熟患儿较轻而已；环境内分泌干扰物的污染与儿童性早熟的发病有密切关系，是其重要的致病因素之一；不同种类的环境内分泌干扰物对靶器官的致病作用强度有所不同。

In recent ten-odd years the pathogenetic regularity of female idiopathic precocious puberty was researched in our hospital, in terms of the function of hypothalamic-pituitary-gonadal axis and the status of skeletal development as indicators. The regime of the therapy with a predominance of Chinese herbal medicine (CHM) was formulated, according to recognition for the regularity of differential diagnosis with method of traditional Chinese medicine (TCM). It has been clinically verified that the regime could successfully modulate the course of pubertal development and optimize skeletal development in children with precocious puberty. The mechanism of effectiveness of the drugs has been further researched focusing of the neuroendocrine regulation and gene expression with modern medical technique.