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段宏泉, Hongquan Duan, † Yoshihisa Takaishi, *, † Yasuhiro Imakura, ‡ Yongfong Jia, § Duan Li, § L. Mark Cosentino, ⊥and Kuo-Hsiung Lee‖|
J. Nat. Prod. 2000, 63, 357~361,-0001,():
-1年11月30日
Five new sesquiterpene pyridine alkaloids [triptonines A (1) and B (2), and wilfordinines A (3), B (4), and C (5)] and two known compounds (peritassine A and hypoglaunine C) were isolated from Tripterygium hypoglaucum and a clinically used extract of Tripterygium wilfordii. The structures of 1-5 were elucidated by spectroscopic methods. The anti-HIV activity of 1, 2, and several related compounds was evaluated. Triptonine B (2) demonstrated potent anti-HIV activity with an EC50 value of <0.10
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【期刊论文】Triterpenoids from Tripterygium wilfordii
段宏泉, Hongquan Duan a, Yoshihisa Takaishi a, *, Hiroshi Momota b, Yasukazu Ohmoto b, Takao Taki b, Yongfeng Jia c, Duan Li c
Phytochemistry 53(2000)805~810,-0001,():
-1年11月30日
The extract (TII) of Tripterygium wilfordii Hook f. afforded four triterpenoids: wilforic acid D (3b,24-epoxy-2a-hydroxy-24R*-ethoxy-29-friedelanoic acid); (E) 3b,24-epoxy-2-oxo-3a-hydroxy-29-friedelanoic acid; (F) 2b-hydroxy-3-oxo-friedelan-29-oic acid; 29-hydroxy-3-oxo-olean-12-en-28-oic acid and 17 known triterpenoids. Their structures were established on the basis of spectroscopic studies. In a bioactivity analysis, only the known dulcioic acid compound showed a signi
Tripterygium wilfordii, Triterpenoids, Immunosuppressive activity
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【期刊论文】Sesquiterpene polyol esters from Tripterygium wilfordii
段宏泉, Hong-Quan Duan a, Yoshihisa Takaishi a, *, Yong-Feng Jia b, Duan Li b
Phytochemistry 56(2001)341~346,-0001,():
-1年11月30日
The extract (TII) of Tripterygium wilfordiiHook f. afforded four sesquiterpene esters: 1β, 2β,5a, 8β,11-pentaacetoxy-4a-hydroxy-3a(2'-methylbutanoyl)-15-nicotinoyl-7-oxo-dihydroagarofuran; 1β,5a,11-triacetoxy-7β-benzoyl-4a-hydroxy-8+-nicotinoyl-dihydroagarofuran;1β,2β,5a,11-tetraacetoxy-8a-benzoyl-4a-hydroxy-7β-nicotinoyl-dihydroagarofuran; 5a-benzoyl-4a-hydroxy-1β,8a -dinicotinoyl-dihydro-agarofuran as well as one other known sesquiterpene ester. Their structures were established on the basis of spectroscopic studies.
Tripterygium wilfordii, Celastraceae, TII, Sesquiterpene esters
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【期刊论文】Immunosuppressive constituents from Saussurea medusa
段宏泉, Hongquan Duan a, Yoshihisa Takaishi a, *, Hiroshi Momota b, Yasukazu Ohmoto b, Takao Taki b
Phytochemistry 59(2002)85~90,-0001,():
-1年11月30日
The methanol extract of Saussurea medusa Maxim afforded two lignans: 2a-guaicyl-4-oxo-6a-catechyl-3,7-dioxabicyclo [3.3.0]octane and 1a-hydroxy-2a,4a-guaicyl-3,7-dioxabicyclo[3.3.0]octane; two chlorophyll derivatives: 13-epi-phaeophorbide-a and 13-epi-phaeophorbide-a methyl ester; one megastigmane derivative: 3b-hydroxy-5a,6a-epoxy-7-megastigmen-9-one, along with 19 known compounds. Their structures were established on the basis of spectroscopic studies.
Saussurea medusa, Compositae, Lignan, Phaeophorbide, Immunosuppressive activity
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【期刊论文】Immunosuppressive terpenoids from extracts of Tripterygium wilfordii
段宏泉, Hongquan Duan, a, Yoshihisa Takaishi, *, Hiroshi Momota, b, Yasukazu Ohmotoo, Takao Taki, Motoo Tori, c, Shigeru Takaoka, Yongfeng Jia, d, and Duan Lid
Tetrahedron 57(2001)8413~8424,-0001,():
-1年11月30日
The dlinically uded extract (TⅡ) of Tripterygium wilfordii Hook f. give 19 new compounds, including five kaurane diterpenes (1-5), one manoyl oxide diterpene (6), and one abietane diterpene (7), three ursene triterpenes (8,9and15), six oleanane triterpenes (10-13,16and19), and three friedelane triterpenes (14, 17and18), as well ad 15 known compounds (20-34). Their structures were elucidated by spectroscopy and X-ray analysis. Based on the screening of isolated compounds and other compounds reported in previous papers [J. Nat. Prod. 62 (1999) 1522; J. Nat. Prod. (2001) in press; Phytochemistry 53 (2000) 805], we identified the main components that are responsible for the therapeutic effect of TⅡ.
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