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2005年07月13日

【期刊论文】Immunosuppressive terpenoids from extracts of Tripterygium wilfordii

段宏泉， Hongquan Duan， a， Yoshihisa Takaishi， *， Hiroshi Momota， b， Yasukazu Ohmotoo， Takao Taki， Motoo Tori， c， Shigeru Takaoka， Yongfeng Jia， d， and Duan Lid

Tetrahedron 57(2001)8413～8424，-0001，（）：

-1年11月30日

摘要

The dlinically uded extract (TⅡ) of Tripterygium wilfordii Hook f. give 19 new compounds, including five kaurane diterpenes (1-5), one manoyl oxide diterpene (6), and one abietane diterpene (7), three ursene triterpenes (8,9and15), six oleanane triterpenes (10-13,16and19), and three friedelane triterpenes (14, 17and18), as well ad 15 known compounds (20-34). Their structures were elucidated by spectroscopy and X-ray analysis. Based on the screening of isolated compounds and other compounds reported in previous papers [J. Nat. Prod. 62 (1999) 1522; J. Nat. Prod. (2001) in press; Phytochemistry 53 (2000) 805], we identified the main components that are responsible for the therapeutic effect of TⅡ.

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2005年07月13日

【期刊论文】Immunosuppressive Sesquiterpene Alkaloids from Tripterygium wilfordii

段宏泉， Hongquan Duan， † Yoshihisa Takaishi， *， † Hiroshi Momota， ‡ Yasukazu Ohmoto， ‡ Takao Taki， ‡ Yongfeng Jia， § and Duan Li§

J. Nat. Prod. 2001, 64, 582～587，-0001，（）：

-1年11月30日

摘要

Nine new sesquiterpene pyridine alkaloids [wilfornines A (1), B (2), C (3), D (4), E (5), F (8), and G (9); wilfordinines I (6) and J (7)] and six known compounds (10-15) were isolated from a clinically used extract (TII) of Tripterygium wilfordii. The structures of 1-9 were elucidated by spectroscopic and chemical methods. The inhibitory effects on cytokine production of 1-3 and several related compounds were evaluated. Compounds 10 and 14 showed significant inhibitory effects on cytokine production.

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2005年07月13日

【期刊论文】SESQUITERPENE ALKALOIDS FROM TRIPTER YGIUM HYPOGLA UCUM

段宏泉， HONGQUAN DUAN， KAZUYOSHI KAWAZOE and YOSHIHSA TAKAISHI*

Phytochemistry, Vol. 45, No.3, pp. 617～621, 1997，-0001，（）：

-1年11月30日

摘要

Esters of three new (hyponines A-C) and four known sesquiterpene polyalcohol esters have been isolated from the root bark of Tripterygium hypoglaucum. The structures of the new compounds were elucidated at 7-(acetyloxy)-OS-furanoyl-OS-deacetyl-7-deoxo-evonine, 7-(acetyloxy)-O11-furanoyl-O11-deacetyl-7-deoxo-evonine and 7-(acetyloxy)-O11-benzoyl-O11-deacetyl-7-deoxo-evonine by spectroscopic means. This structural elucidation indicated that the structure of the known compound should be reversed.

Index-Tripterygium hypoglaucum， Celastraceae， root bark， sesquiterpenes， alka-loids， evonine， hyponine.，

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2005年07月13日

【期刊论文】Polysulfide Derivatives from Ferula foetida

段宏泉， Hongquan Duan， †， Yoshihisa Takaishi， *， ‡， Motoo Tori， §， Shigeru Takaoka， Gisho Honda， ⊥， Michiho Ito， Yoshio Takeda， ‖， Olimjon K. Kodzhimatov， ▽， K. Kodzhimatov， and Ozodbek Ashurmetov▽

J. Nat. Prod. 2002, 65, 1667～1669，-0001，（）：

-1年11月30日

摘要

The ethyl acetate-soluble fraction from a methanol extract of Ferula foetida has afforded six new sulfide derivatives, (E)-3-methylsulfinyl-2-propenyl sec-butyl disulfide (foetisulfide A) (1), (Z)-3-methylsulfinyloxy-2-propenyl sec-butyl disulfide (foetisulfide B) (2), (E)-3-methylsulfinyloxy-2-propenyl sec-butyl disulfide (foetisulfide C) (3), bis(3-methylthio-2E-propenyl) disulfide (foetisulfide D) (4), 3,4,5-trimethyl-2-thiophenecarboxylic acid (foetithiophene A) (5), 3,4,5-trimethyl-2-(methylsulfinyloxymethyl)thiophene (foetithiophene B) (6), along with six known compounds. The structures of 1-6 were established on the basis of spectroscopic studies, with the elucidation of 5 confirmed by single-crystal X-ray crystallography.

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2005年07月13日

【期刊论文】Immunosuppressive Diterpenoids from Tripterygium wilfordii

段宏泉， Hongquan Duan， † Yoshihisa Takaishi， *， † Hiroshi Momota， ‡ Yasukazu Ohmoto， ‡ Takao， Taki， ‡ Yongfeng Jia， § and Duan Li§

J. Nat. Prod. 1999, 62, 1522～1525，-0001，（）：

-1年11月30日

摘要

A clinically used extract of Tripterygium wilfordii afforded three new diterpenoidss3

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