中国科技论文在线

上传时间

2005年07月13日

段宏泉， Hiroyuki NAKAGAWA， Hongquan DUAN， and Yoshihisa TAKAISHI*

Chem. Pharm. Bull. 49(5)649～651 (2001)，-0001，（）：

-1年11月30日

Four new limonoid derivatives, l-O-methylichangensin (I), sudachinoid A (2), B (3), and C (4) were isolated from the seeds of Citrus sudachi, together with the known compounds ichangensin, obacunone, obacunoic acid and limonin, and the structures of the new compounds were elucidated based on spectroscopic and chemical evidence.

Citrus sudachi， Rutaceae， limonoid， sudachinoid

66浏览
0点赞
0收藏
0分享
189下载
0

引用

上传时间

2005年07月13日

【期刊论文】Immunosuppressive terpenoids from extracts of Tripterygium wilfordii

段宏泉， Hongquan Duan， a， Yoshihisa Takaishi， *， Hiroshi Momota， b， Yasukazu Ohmotoo， Takao Taki， Motoo Tori， c， Shigeru Takaoka， Yongfeng Jia， d， and Duan Lid

Tetrahedron 57(2001)8413～8424，-0001，（）：

-1年11月30日

摘要

The dlinically uded extract (TⅡ) of Tripterygium wilfordii Hook f. give 19 new compounds, including five kaurane diterpenes (1-5), one manoyl oxide diterpene (6), and one abietane diterpene (7), three ursene triterpenes (8,9and15), six oleanane triterpenes (10-13,16and19), and three friedelane triterpenes (14, 17and18), as well ad 15 known compounds (20-34). Their structures were elucidated by spectroscopy and X-ray analysis. Based on the screening of isolated compounds and other compounds reported in previous papers [J. Nat. Prod. 62 (1999) 1522; J. Nat. Prod. (2001) in press; Phytochemistry 53 (2000) 805], we identified the main components that are responsible for the therapeutic effect of TⅡ.

58浏览
0点赞
0收藏
0分享
98下载
0

引用

上传时间

2005年07月13日

【期刊论文】Immunosuppressive Sesquiterpenes from Tripterygium wilfordii

段宏泉， Xiaodong WANG a， Wenyuan GAO a， ZhiYAO b， Shaoyu Zhang c， Yanwen ZHANG， c， Yoshihisa TAKAISHI， d， and Hongquan DUAN*e

Chem. Pharm. Bull. 53(6)607～610 (2005)，-0001，（）：

-1年11月30日

摘要

Five new sesquiterpenes, 1β-furanoyl-2β, 3a, 7a, 8β, 11-pentaacetoxy-4a, a-dihydroxy-dihydroagarofuran (1), 1β, 2β, 3a, 5a, 7β, 8β, 11-heptaacctoxy-dihydroagarofuran (2), 1β-furanoyl-2β,3a, 7a, 8β, 11-pentaacetoxy-5a-hydroxy-dihydroagarofuran (3), 1β, 7β, 8a-triacctoxy-2fl-furanoyl-4a-hydroxy-11-isobutyryloxy-dihydroagarofu-ran (4), and 1β-nicotinoyl-2β, 5a, 7β-triacetoxy-4a-hydroxy-11-isobutyryloxy-8a-furanoyl-dihydroagarofuran (5), were isolated from the xylem of Tripterygium wilfordii, together with a known compound (6). Their structures were elucidated on the basis of spectroscopic studies. Compounds 2-5 showed significant immunosuppressive activities.

Tripterygium wilfordii， xylem， sesquiterpene， immunosuppressive activity

35浏览
0点赞
0收藏
0分享
62下载
0

引用

上传时间

2005年07月13日

【期刊论文】Immunosuppressive Sesquiterpene Alkaloids from Tripterygium wilfordii

段宏泉， Hongquan Duan， † Yoshihisa Takaishi， *， † Hiroshi Momota， ‡ Yasukazu Ohmoto， ‡ Takao Taki， ‡ Yongfeng Jia， § and Duan Li§

J. Nat. Prod. 2001, 64, 582～587，-0001，（）：

-1年11月30日

摘要

Nine new sesquiterpene pyridine alkaloids [wilfornines A (1), B (2), C (3), D (4), E (5), F (8), and G (9); wilfordinines I (6) and J (7)] and six known compounds (10-15) were isolated from a clinically used extract (TII) of Tripterygium wilfordii. The structures of 1-9 were elucidated by spectroscopic and chemical methods. The inhibitory effects on cytokine production of 1-3 and several related compounds were evaluated. Compounds 10 and 14 showed significant inhibitory effects on cytokine production.

36浏览
0点赞
0收藏
0分享
92下载
0

引用

上传时间

2005年07月13日

【期刊论文】Immunosuppressive Diterpenoids from Tripterygium wilfordii

段宏泉， Hongquan Duan， † Yoshihisa Takaishi， *， † Hiroshi Momota， ‡ Yasukazu Ohmoto， ‡ Takao， Taki， ‡ Yongfeng Jia， § and Duan Li§

J. Nat. Prod. 1999, 62, 1522～1525，-0001，（）：

-1年11月30日

摘要

A clinically used extract of Tripterygium wilfordii afforded three new diterpenoidss3

42浏览
0点赞
0收藏
0分享
76下载
0

引用