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杨新林, Xinlin Yang, Lin Chen, Xinge Qiao, Cuihong Fan
International Journal of Toxicology, 26: 197-201, 2007,-0001,():
-1年11月30日
The biological activities of fullerene derivatives have attracted much attention in the last decade. In this paper, effects of dimalonic acid C60 (DMA C60) on cytoplasmic membrane, intracellular calcium concentration ([Ca2+]i), and mitochondrial membrane in HeLa cells were studied by using laser scanning confocal microscopy together with fluorescent probes propidium iodide (PI), fluo-3 acetoxymethyl ester (fluo-3 AM), and tetramethyl rhodamine methyl ester (TMRM). The data showed that under laser irradiation produced by a Kr/Ar laser source with a low power less than 1 mW, DMA C60 might induce damages against both cytoplasmic and mitochondrial membranes in a time- and dose-dependent manner. Prior to leakage of cytoplasmic membrane, a transient increase in [Ca2+]i occurred due to influx of calcium from the culture medium. These data provided some novel clues to explain the mechanisms involved in the photo-induced cytotoxicity of fullerene derivatives.
Calcium Signal, Cytoplasmic Membrane, Dimalonic Acid C60, Laser Scanning Confocal Microscopy, Mitochondrial Membrane, Photo-Induced Damage
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杨新林, X.L. Yang , C. Huang, X.G. Qiao, L. Yao, D.X. Zhao, X. Tan
Toxicology in Vitro XXX(2007)XXX-XXX,-0001,():
-1年11月30日
Using human erythrocyte membranes (EMs) as a model system, we have examined photo-induced lipid peroxidation by a bis-methanophosphonate fullerene (BMPF) and four other fullerene derivatives including a mono-methanophosphonic acid fullerene (MMPF), a dimalonic acid C60 (DMA C60), a trimalonic acid C60 (TMA C60) and a polyhydroxylated fullerene (fullerol). Lipid peroxidation was assessed as the malondialdehyde (MDA) level measured by the thiobarbituric acid assay. It was observed that BMPF increased the MDA level of EMs after irradiation in both time- and dose-dependent manners. The photo-induced activity became very significant (p < 0.01) under the conditions of either the concentration of 10 μM and irradiation time of 30 min or the concentration of μ5 M and irradiation time of 60 min. Involvement of reactive oxygen species (ROS) in the activity was also examined by specific inhibitors of singlet oxygen, superoxide anions and hydroxyl radicals, respectively. While all three kinds were found responsible for the activity, the former two might play more important roles than the last one. Furthermore, the activity of BMPF was the strongest among all tested fullerene derivatives. These results indicated BMPF was a potential photosensitizer that would find application in photodynamic therapy.
Bis-methanophosphonate fullerene, Human erythrocyte membranes, Irradiation, Lipid peroxidation, Reactive oxygen species
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【期刊论文】Synthesis and optical properties of tetraethyl methano [60] fullerenediphosphonate
杨新林, Fuyong Cheng, a Xinlin Yang, a Hesun Zhua* and Yinglin Songb
Tetrahedron Letters 41 (2000) 3947-3950,-0001,():
-1年11月30日
A novel C60 organophosphonate derivative, tetraethyl methano [60] fullerenediphosphonate 2, was synthesized by the reaction of C60 with tetraethyl methylenediphosphonate 1 in the presence of I2 and NaH. It has high solubility in polar solvents and the nonlinear optical properties of the new compound were better than those of C60.
C60, tetraethyl methylenediphosphonate, optical limiting, third-order nonlinear.,
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杨新林, H.-S. Zhu, X.-L. Yang, L.-B.Wang, D.-X. Zhao and L. Chen
Cell Biology and Toxicology. 2000; 16: 201-206.,-0001,():
-1年11月30日
The e
calcium, cell cycle, cell growth, Ganoderma lucidum, spores
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【期刊论文】单加成环丙烷富勒烯膦酸酯衍生物的合成与电化学性能
杨新林, YANG, Xin-Lin, QIAO, Xin-Ge, ZHU, Zhang-Guang, CHENG, Fu-Yong, He-Sun, FAN, Lou-Zhen
有机化学2006年第26卷第11期, 1557-1561/Chinese Journal of Organic Chemistry Vol. 26, 2006 No. 11, 1557-1561,-0001,():
-1年11月30日
在Mn(OAc)3•2H2O 催化下, C60分别和亚甲基二膦酸四乙酯、氰基亚甲基膦酸二乙酯或乙氧羰基亚甲基膦酸二乙酯在氯苯中回流, 生成3个单加成环丙烷富勒烯膦酸衍生物C60C(R)PO(OEt)2 [1, R=PO(OEt)2; 2, R=COOEt; 3, R=CN]. 与以前报道的Bingel反应法相比, 该方法副产物少并且缩短了反应时间. 采用循环伏安法发现1, 2的还原电位相对于C60发生负移, 而3的还原电位相对于C60却正移40 mV, 表明引入象氰基一样具有很强吸电子能力的取代基团, 可以改善富勒烯球的电化学性能, 合成电子接受能力较强的富勒烯衍生物.
单加成环丙烷富勒烯膦酸衍生物, 合成, 电化学性能, 循环伏安法
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