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【期刊论文】Synthesis of oligoadducts of malonic acid C60 and their scavenging effects on hydroxyl radical
杨新林, Fuyong Chenga, Xinlin Yanga, Hesun Zhua, *, Jian Sunb, Yang Liub
Journal of Physics and Chemistry of Solids 61 (2000) 1145-1148,-0001,():
-1年11月30日
Seven malonate derivatives of C60 with different addition number and regiostructure were obtained by the "one-pot" reaction of C60 with diethyl bromomalonate (1:6) and subsequent separation by silica gel chromatography. The corresponding malonic acid derivatives of C60 were formed by hydrolyzing with NaH and CH3OH. Four of them with different addition number (C60(C(COOH)2)n, n
Malonic acid C60, ", One-pot", synthesis, Scavenging activity, Hydroxyl radical
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杨新林, Fuyong Cheng, Xinlin Yang, Cuihong Fan and Hesun Zhu*
F. Cheng etal. /Tetrahedron 57 (2001) 733-7335,-0001,():
-1年11月30日
Synthesis of novel methanophosphonate and methanophosphonic acid C60 derivatives was achieved, and their cytotoxicity was studied. In particular, a bis-methanophosphonate C60 derivative displayed photo-induced cytotoxicity on HeLa cells with IC50 value of 1.30
fullerene, organophosphorus compounds, photo-induced, cyto-toxicity.,
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杨新林, Jinwei Gu, Xinlin Yang*, Hesun Zhu
Materials Science and Engineering C 20 (2002) 199-202,-0001,():
-1年11月30日
To improve the blood compatibility of Bombyx mori silk fibroin (SF) film, the film was modified by SO2 gas plasma treatment, or by a two-step process including NH3 gas plasma treatment and reaction with 1, 3-propane sultone. XPS and ATR-FTIR were used to analyze the surface chemical elements. In vitro antithrombogenicity was determined by the method of the activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) tests. Percents of sulfur element on the surfaces of both modified SF films were 4.03% and 3.30%, respectively, while that of the control film was only 0.32%. Moreover, the antithrombogencity of treated films was increased remarkably due to surface sulfonation. The results implied a potential use of sulfonated SF for blood-contacting biomaterials.
Silk fibroin (, SF), , Plasma, Antithrombogenicity
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杨新林, X. L. Yang*, C. H. Fan, H. S. Zhu
Toxicology in Vitro 16 (2002) 41-46,-0001,():
-1年11月30日
Photo-induced cytotoxicity of malonic acid [C60] fullerene derivatives and its mechanism X. L. Yang*, C. H. Fan, H. S. Zhu Research Center of Materials Science, Beijing Institute of Technology, PO Box 327, Beijing 100081, PR China Accepted 10 August 2001 The biological activities of fullerenes have attracted extensive attention in recent years. The aim of this paper is to study the relation of the photo-induced cytotoxicity of fullerene derivatives to their chemical structures as well as the possible cellular mechanism involved in the photocytotoxicity. Three C60 derivatives with two to four malonic acid groups (DMA C60, TMA C60 and QMA C60) were prepared and the cytotoxicity of these compounds against HeLa cells was determined by MTT. Cell cycle was measured by flow cytometry. The results showed that the cytotoxicity of the malonic acid C60 derivatives was irradiation-and dosedependent. The sequence of their photo-induced growth inhibition was DMA C60>TMA C60>QMA C60. Hydroxyl radical quencher mannitol (10mm) was not able to prevent cells from the damage induced by irradiated DMA C60. DMA C60,together with irradiation,was found to have an ability of inducing a decrease in the number of G1 cells from 63 to 42% and a rise in that of G2+M cells from 6 to 26%. These data indicated that the number of malonic acid molecules added to C60 played an important role in the phototoxicity and the blockage of cell cycle might be a mechanism of this activity.
Cell cycle, Cell growth, Malonic acid C60 derivatives, Photo-induced, Reactive oxygen species
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【期刊论文】Inhibition of a thermophilic deoxyribonucleic acid polymerase by fullerene derivatives
杨新林, XIANMEI MENG, BO LI, ZHE CHEN, LU YAO, DONGXU ZHAO, XINLIN YANG, MIN HE, QUN YU
fournal of Enzyme Inhibition and Medicinal Chemistry, June 2007; 22(3): 293-296,-0001,():
-1年11月30日
Enzyme inhibition by fullerene derivatives has attracted much attention. In this communication, effects of two water-solube fullerene derivatives, fullerol and trimalonic acid C60 (TMA C60) on polymerase chain reaction (PCR) were investigated by using PCR of β-actin cDNA derived from HeLa cells as an experimental model. Both fullerol and TMA C60 were found to inhibit PCR in a dose-dependent manner. PCR was ultimately inhibited while the concentrations of each compound were not less than 0.01mM. In contrast, mannitol exerted no effects on PCR while its concentration increased up to 2mM. Compensation experiments with Thermus aquaticus (Taq) DNA polymerase revealed that both fullerol andTMAC60 inhibited the enzymatic activity of Taq DNA polymerase, and the inhibitory potency of TMA C60 was slightly greater than that of fullerol. Our data provides some novel aspects on the enzyme inhibiting activities of fullerene derivatives.
Fullerol, trimalonic acid C60, Taq DNA polymerase, inhibition
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