中国科技论文在线

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2005年06月18日

【期刊论文】Surface sulfonation of silk fibroin filmby plasma treatment and invitro antithrombogenicity study

杨新林， Jinwei Gu， Xinlin Yang*， Hesun Zhu

Materials Science and Engineering C 20 (2002) 199-202，-0001，（）：

-1年11月30日

To improve the blood compatibility of Bombyx mori silk fibroin (SF) film, the film was modified by SO2 gas plasma treatment, or by a two-step process including NH3 gas plasma treatment and reaction with 1, 3-propane sultone. XPS and ATR-FTIR were used to analyze the surface chemical elements. In vitro antithrombogenicity was determined by the method of the activated partial thromboplastin time (APTT), prothrombin time (PT) and thrombin time (TT) tests. Percents of sulfur element on the surfaces of both modified SF films were 4.03% and 3.30%, respectively, while that of the control film was only 0.32%. Moreover, the antithrombogencity of treated films was increased remarkably due to surface sulfonation. The results implied a potential use of sulfonated SF for blood-contacting biomaterials.

Silk fibroin (， SF)，， Plasma， Antithrombogenicity

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2005年06月18日

【期刊论文】Organophosphorus chemistry of fullerene: synthesis and biological iffects of ofganophosphorus compounds of C60

杨新林， Fuyong Cheng， Xinlin Yang， Cuihong Fan and Hesun Zhu*

F. Cheng etal. /Tetrahedron 57 (2001) 733-7335，-0001，（）：

-1年11月30日

摘要

Synthesis of novel methanophosphonate and methanophosphonic acid C60 derivatives was achieved, and their cytotoxicity was studied. In particular, a bis-methanophosphonate C60 derivative displayed photo-induced cytotoxicity on HeLa cells with IC50 value of 1.30

fullerene， organophosphorus compounds， photo-induced， cyto-toxicity.，

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2005年06月18日

【期刊论文】Synthesis of oligoadducts of malonic acid C60 and their scavenging effects on hydroxyl radical

杨新林， Fuyong Chenga， Xinlin Yanga， Hesun Zhua， *， Jian Sunb， Yang Liub

Journal of Physics and Chemistry of Solids 61 (2000) 1145-1148，-0001，（）：

-1年11月30日

摘要

Seven malonate derivatives of C60 with different addition number and regiostructure were obtained by the "one-pot" reaction of C60 with diethyl bromomalonate (1:6) and subsequent separation by silica gel chromatography. The corresponding malonic acid derivatives of C60 were formed by hydrolyzing with NaH and CH3OH. Four of them with different addition number (C60(C(COOH)2)n, n

Malonic acid C60， "， One-pot"， synthesis， Scavenging activity， Hydroxyl radical

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2005年06月18日

【期刊论文】Synthesis and optical properties of tetraethyl methano [60] fullerenediphosphonate

杨新林， Fuyong Cheng， a Xinlin Yang， a Hesun Zhua* and Yinglin Songb

Tetrahedron Letters 41 (2000) 3947-3950，-0001，（）：

-1年11月30日

摘要

A novel C60 organophosphonate derivative, tetraethyl methano [60] fullerenediphosphonate 2, was synthesized by the reaction of C60 with tetraethyl methylenediphosphonate 1 in the presence of I2 and NaH. It has high solubility in polar solvents and the nonlinear optical properties of the new compound were better than those of C60.

C60， tetraethyl methylenediphosphonate， optical limiting， third-order nonlinear.，

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