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游松, 张予阳, 于庆海, 盛丽, 孙萍
中国药理学通报,2001,17(6):667~669,-0001,():
-1年11月30日
目的:研究银杏内酯(TG)对小鼠密闭缺氧、急性脑缺血和大鼠局灶性脑缺血的保护作用。方法:采用小鼠密闭缺氧实验,观察TG对耗氧速度和存活时间的影响;结扎小鼠双侧颈总动脉及迷走神经造成脑缺血,观察TG对死亡率及死亡时间的影响:电凝大鼠一侧大脑中动脉造成局灶性脑缺血(MCAO),观察TG对脑梗塞面积、行为及组织病理形态的影响。结果:TG(32mg·kg-1)降低脑缺血小鼠的死亡率,延长死亡时间:4,8,16mg·kg-1降低MCAO大鼠脑梗塞范围,改善行为障碍及脑组织病理形态。以密闭缺氧小氧耗氧速度、存活时间无影响。结论:银杏内酯具有抗脑缺血作用。
银杏内酯, 局灶性脑缺血, 脑梗塞面积, 耗氧量, 耗氧速度, 脑缺血
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游松, 王亮
沈阳药科大学学报,2001,18(3):217~222,-0001,():
-1年11月30日
近20多年以来,随着分子生物学的不断发展,植物基因工程取得了很多突破,本文介绍了转基因植物在生物药品、食品、工业用酶和农业四方面的发展现状。
转基因植物, 综述, 生物药品, 食品, 工业用酶, 农作物
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游松, Koji Ichinose a, Song You b, Noriaki Kawano a, Kaori Hayashi a, Xin-Sheng Yao b, Yutaka Ebizuka a, *
Phytochemistry 51(1999)599-603,-0001,():
-1年11月30日
Furostanol glycoside 26-O-b-glucosidase (F26G) is a specific b-glucosidase converting a furostanol glycoside (FG) to its corresponding spirostanol glycoside (SG). A cDNA encoding F26G from Costus speciosus was introduced into a heterologous plant, Nicotiana tabacum via Agrobacterium tumefaciens using a binary vector method. Successful integration of the cDNA into tobacco chromosomal DNA was confirmed by PCR analysis. F26G activity was also detected in cell-free extracts of the transgenic plantlets.
Costus speciosus, Zingiberaceae, b-glucosidase, Furostanol glycoside, Steroid saponin, Spirostanol glycoside, Agrobacterium tumefaciens, Nicotiana tabacum
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游松, Song YOUI ), Nonaki KAWANO ), Kojl ICHINOSE l), Xm Sheng YA ), and Yutaka EBIZUKA * )
Plant Biotechnology, 16(4), 311-314(1999),-0001,():
-1年11月30日
Plant oxidosqualene cyclase (OSC) is classified into two types depeneding on its catalytic mechanisms and products: cycloartenol synthase and triterpene synthase. A cDNA probably encoding OSC was cloned from bulbs of Allium macrostemon by RT-PCR. The cDNA contains a 2289-bp open reading frame, encoding 762 amino acids. A higher degree of homology (73 %) was fcund for the gene product with the known cycloartenol synthases than with the triterpene synthases (51-55 %), indicating its most likely function as cycloartenol synthase. This is the first cloning example of a putative cDNA encoding OSC from a monocotyledonous plant.
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