A clinical and laboratory analyrsis of the dYnamlc change of plasma cortisol level in tw0 groups of chiIdren with neDhrotic syndrome has been made-a combined treatment group and a control group. The former was given long-term large dosage prednisone co rnbined with "Z1 Yin Jiailg Huo" and "Wen Bu Shen Yang" drugs, while the latter received no traditionaI medieine during pred-nisone administration The aim of the present study is to find Out whether tra-ditional medicines can protect the adrenal cortex. and antagonize the negative feed-back action Of exogenous steroid, thereby providing a theoretical and labora tory basis for dinical use of traditional medicines in reducing severe side effects of large dosage of steroid. Our results show: 1. Large dosage prednisone, either given daily in diVided doses or once every other day, can significantly suppress the adrenocortical activity, and the suppressive action decreases along with taper-ing off of the dosage of prednisone. 2. "Wen Bu Shen Yang" drugs can remark ably protect the adrenal eortex and antagonize the negative feed-back action of exogenous glucocorticosteroid. 3. "Zi Yin Jiang Huo" drugs possess no significant influence on plasma cortisoI level during long-term large dosage steroid therapy.

我们测定了42例单纯性肥胖症小儿的肾上腺皮质功能，结果显示：①1/3的患儿血浆总皮质醇(PTC)昼夜节律正常，而其余2/3的患儿存在不同程度、不同类型的异常；②展游离皮质醇(UFC)的含量在正常范围；③地塞米辁抑制筛查试验正常。表明多数单纯性肥胖症患儿的肾上腺皮质功能活动水平较高，但对地塞米松的反馈抑制作月仍十分敏感，与正常小儿及柯兴综台征患者均有显著不同。

Objective: To find effective therapeutic approach f。r treating true idi。pathic precocious pubertv suitable to OU F national condilion and different from gonadotrophin releasing hormone aIlalogue Metbs: Onc hundred and SIX gifts with idiopathic precocious puberty were divided into 3 groups The 51 girls in the TCM WM group were treated with Chinese herbal medicine combined with megestr. l acctatc(MA), 35 girls in the MA group treated with megestrol acetate alone, and 20 girls were taken 8s control group and given n. trea LIncnt at all Luteinizing hormone releasing hormone (LHRH) sticau]ating test were performed before and after treat ment, and the size ol the uterus and ovary, linear growth rate, X-ray bone age measurement and final heighy prediction were also observed simultaneously Results：Aher t reared with TCM WM for 27 years in average, the luteinizing hormone (LH) peak value of LHRH stimulating test was reduced front 48.5±5.2 IU/L FO 12 2±1.3IU/L, size of uterus and Ovary decreased, secondary sexual characteristics rezressed, the bone age difterence/chronoIogical age difference value (ABA/ACA) reduced from 1.35±0.09 to 0.65+0.05 and predictive final height increased front 153.3±0.5cm to 158.5+0.6cm. Conclusion: TCM-WM therapy could not only modulate the function of hypothalamic-pltuitary-ovarian axis and the development of internal, genhalia. but also cluld decelerate skeletal growth, delay skeletal maturation, and thereby prevent premature epiphyseal fusion and increase the final height of patiehts.

肾阴肾阳失衡是性早熟和衰老的病理基础，衰老是“生理性肾虚”，其阴阳失衡是以肾阳虚为主；性早熟的本质是阴虚火旺，其阴阳失调是以肾阴虚为主。由肾气盛衰主导的生长、发育、衰老过程中，主要涉及生长激素轴和性腺轴，性早熟惠儿可见这两轴的提前启动，表现为阴虚火旺；而衰老时是这两轴的率先衰退，表现为阳气虚损。分别采用温补肾阳方药以延缓衰老与滋阴泻火方药以抑制性早熟取得临床与实验的显著效果，通过以药测证，推测发病部位，证明性早熟或衰老，其病理损害是在下丘脑或更高中枢。