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【期刊论文】Microfluidic chips for cells capture using 3-D hydrodynamic structure array
陈景东, Jingdong Chen, Di Chen, Tao Yuan, Xiang Chen, Jun Zhu, Andreas Morschhauser, Joerg Nestler, Thomas Otto and Thomas Gessner
Microsyst. Technol. 2014, 20 (3): 485-491.,-0001,():
-1年11月30日
Microfluidic chips were designed and fabricated to capture cells in a relative small volume to generate the desired concentration needed for analysis. The microfluidic chips comprise 3D cell capture structures array fabricated in PDMS. The capture structure includes two layers. The first layer consists of spacers to create small gap between the upper layer and glass. The second layer is a sharp corner U-shaped compartment with sharp corners at the fore-end. And another type capture structure with Y-shaped fluidic guide has been designed. It was demonstrated that the structures can capture cells in theory, using Darcy-Weisbach equation and COMSOL Multiphysics. Then yeast cell was chosen to test the performance of the chips. The chip without fluid guides captured approximately 1.44×105 cells and the capture efficiency was up to 71%. And the chip with fluid guides captured approximately 5.0×104 cells and the capture efficiency was approximately 25%. The chip without fluid guides can capture more cells because the yeast cells in the chip without fluid guides are subject to larger hydrodynamic drag force.
Microfluidic chip, cells capture, hydrodynamic structure, 3-D
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【期刊论文】The design and fabrication of a low-field NMR probe based on a multilayer planar microcoil
陈景东, Weiping Wu, Hong Yi, Di Chen, Rongsheng Lu, Tao Yuan, Jingdong Chen and Zhonghua Ni
Microsyst. Technol. 2014, 20 (3): 419-425.,-0001,():
-1年11月30日
The nuclear magnetic resonance (NMR) probe has great influence on signal transmission and reception in NMR technology applications. In this paper, we present a design, fabrication, and test of an NMR probe comprised of a multilayer planar microcoil with a polydimethylsiloxane (PDMS) microchannel. First, geometric parameters of the probe are determined through theoretical analysis. Second,based on a glass substrate, the multilayer planar microcoil is manufactured using repeated photolithography and electroplating processes. During the fabrication process,the polyimide layer is used to package the coil, and the PDMS interlayer is used to adjust the distance from centerlines between the coil and the sample chamber. Third,the resistance and the quality factor of the coil are found to be 1.2158 X and 7.217, respectively, at a Larmor frequency of 28.1 MHz. Finally, the NMR probe is tested in an NMR experiment. The transverse relaxation time T2 for the solid PDMS is 20.6 ± 0.4 ms, which is in agreement with 21.1 ± 0.2 ms obtained by a Bruker Minispec MQ60.Results show that the design and fabrication of this NMR probe are feasible for time-domain NMR applications.
low-field NMR probe, multilayer planar microcoil, polydimethylsiloxane
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【期刊论文】Design, fabrication and characterization of MEMS probe card for fine pitch IC testing
陈景东, Tao Yuan, Di Chen, Jingdong Chen, Hualin Fu, Steffen Kurth, Thomas Otto and Thomas Gessner
Sensors and Actuators A: Physical. 2013, 204: 67-73.,-0001,():
-1年11月30日
tThis article introduces a novel type of MEMS probe card that uses polymer (polydimethylsiloxane, PDMS)as an elastic layer. The elastic layer provides the flexibility when the probes are in contact with the chippads. Through-holes in the PDMS and the low temperature co-fired ceramic (LTCC) substrate lead thesignals or power to the back side of the LTCC substrate. The proposed MEMS probe card configurationpotentially improves the probe density and simplifies the fabrication process. The probes are formedby electroplating on the PDMS substrate. The PDMS elastic substrate probe card with a probe pitch of100 m was developed for area array pad testing. The contact force is approximately 18 mN when theprobes overdrive is 20 m. Coplanar waveguides structures can be fabricated on the PDMS surface. Themeasured insertion loss is 0.2 dB at 3 GHz.The test data exhibited that the PDMS elastic substrate probecard is suitable for high-frequency wafer level IC testing.
Probe card, Polydimethylsiloxane, Elastic substrate, IC testing
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【期刊论文】A novel MEMS elastic-based dry electrode for electroencephalography measurement
陈景东, Tao Yuan, Di Chen, Jingdong Chen, Xiang Chen, Xiaowei Wang and Baoliang Lu
Microsyst. Technol. 2014, 20 (6): 1125-1129.,-0001,():
-1年11月30日
Electroencephalogram (EEG) has been one of the important means to study brain functions and diseases.We fabricated an innovative MEMS elastic-based dry electrode using photolithography and electroforming process.The pitch of elastic-based dry electrode tip is 100 lm.We adopted polydimethylsiloxane as an elastic layer which provides the flexibility when the conductive layer and the electrode tip contact with the skin. This kind of dry electrode array does not need conductive gel during testing procedure. Compared with the traditional Ag/AgCl wet electrode, it greatly reduced the preparation time for EEG measurement and it could make the examinee more comfortable.
MEMS, elastic-based, dry electrode, electroencephalography
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陈景东, 胡锐军, 陈迪, 陈翔, 吴澄, 杜航向, 杨治力, 王志刚, 夏骏
功能材料与器件学报, 2011, 17(2): 227-232.,-0001,():
-1年11月30日
癌症是影响人类健康的重大疾病之一, 如何快速、方便地分离癌细胞已经成为制约临床医学和科学研究的重要问题。本文将磁珠技术与MEMS技术相结合, 提出了一种等边三角排列的N i微磁柱结构, 在磁场作用下使用CD326免疫磁珠捕获结肠癌细胞。本文对MEMS细胞捕获芯片进行了设计、加工和封装, 采用该芯片对与磁珠结合的结肠癌细胞进行了捕获, 0. 1m l/h流速下捕获效率达92%,证明该芯片具有对结肠癌细胞的捕获能力。
结肠癌细胞捕获, 免疫磁珠
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