Phenoporlamine hydrochloride is a novel compound that is used for the treatment of hypertension. The purpose of this study was to develop a sustained release tablet for phenoporlamine hydrochloride because of its short biological half-life. Three floating matrix formulations of phenoporlamine hydrochloride based on gas forming agent were prepared. Hydroxypropyl methylcellulose K4M and Carbopol 971P NF were used in formulating the hydrogel drug delivery system. Incorporation sodium bicarbonate into matrix resulted in the tablet floating over simulated gastric fluid for more than 6 h. The dissolution profiles of all tablets showed non-Fickian diffusion in simulated gastric fluid. Moreover, release of the drug from these tablets was pH-dependent. In vivo evaluations of these formulations of phenoporlamine hydrochloride were conducted in six healthy male human volunteers to compare the sustained release tablets with immediate release tablets. Data obtained in these studies demonstrated that the floating matrix tablet containing more Carbopol was capable of sustained delivery of the drug for longer periods with increased bioavailability and the relative bioavailability of formulation (containing 25% Carbopol 971P NF, 8.3% HPMC K4M) showed the best bioequivalency to the reference tablet (the relative bioavailability was 1.11

茵陈蒿含有香豆索类、色原酮和黄酮类等活性成分，除具有利保保肝作用外，还有镇痛、消炎、降血脂、增强免疫、抗肿瘤作用，值得进一步开发研究。

目的介绍差示扫描量热法（DSC）在蛋白质热变性研究中的应用。方法 以大量具有代表性的文献为依据，讨论如何 运用DSC技术研究蛋白质热变性的原因与影响因素及蛋白质热变性与生理活性的关系。结果与结论DSC在蛋白质热变性研究中的应用有广阔的发展前景。

随着人类社会的老年化，骨质疏松症逐渐成为大众所关注的健康问题。相对其他治疗药物，降钙素由于其有效性和安全性，在抗骨质疏松症治疗的药物中越来越受到重视。现对其结构式、已上市品种及最新给药系统的研究情况及其进展进行了综述。

利用大鼠在体回豌模型，在不同的pH条件下，对酚红的小肠吸收进行了研究。发现酚虹虽然为一离子型的药物，在小肠仍有一定的吸收，其吸收速率为：十二指肠>空肠>回肠>结肠。酚红的吸收受小肠内Ca2+浓度的影响。加入EDTA-Na：能够显著促进酚红的小肠吸收和结肠吸收。实验结果证明：酚红不宜用来标示在体小肠吸收试验中回流液的体积变化。