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2009年07月07日

【期刊论文】Chiral separation of Tamsulosin isomers by HPLC using cellulose Tris(3,5-dimethhylphenylcarbamate) as a chiral stationary phase

杨更亮， Zhefeng Zhang a， Gengliang Yang a， c， ∗， Guijian Liang b， Haiyan Liu a， Yi Chen c

Journal of Pharmaceutical and Biomedical Analysis 34(2004)689-693，-0001，（）：

-1年11月30日

摘要

A high-performance liquid chromatographic (HPLC) method was developed for the chiral separation of an antagonist of alpha1A adrenoceptors, tamsulosin and its S-isomer. Baseline separation of the isomers was achieved within 35 min on a CHIRALCEL OD-RH column with a binary solvent mixture of 50 mmol l−1 KPF6-acetonitrile (v/v (70∶30), pH 5.0) as the optimized mobile phase. The detection limits and quantification limits of both R-isomer and S-isomer were 0.11 and 0.44 ng,respectively. The R.S.D. values of peak-area for the two isomer were 0.42% (of peak-height∶0.77%) for R-isomer and 0.64%(of peak-height∶0.92%) for S-isomer (n=5).

Chiral separation， Tamsulosin (， 5-[(， 2R)， -2-{， [2-(， 2-ethoxyphenoxy)， ethyl]amino}， -propyl]-2-methoxy-benzenesulfonamide)，， Isomer， Cellulose tris(， 3,， 5-dimethylphenylcarbamate)， stationary phase

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河北大学，河北

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